Maglev-fabricated long and biodegradable stent for interventional treatment of peripheral vessels

Wanqian Zhang, Xian Gao, Hongjie Zhang, Guoyi Sun, Gui Zhang, Xin Li, Haiping Qi, Jingzhen Guo, Li Qin, Daokun Shi, Xiaoli Shi, Haifeng Li, Deyuan Zhang (), Wei Guo () and Jiandong Ding ()
Additional contact information
Wanqian Zhang: Fudan University
Xian Gao: Lifetech Scientific (Shenzhen) Co. Ltd.
Hongjie Zhang: Fudan University
Guoyi Sun: First Medical Center of Chinese PLA General Hospital
Gui Zhang: Lifetech Scientific (Shenzhen) Co. Ltd.
Xin Li: Fudan University
Haiping Qi: Lifetech Scientific (Shenzhen) Co. Ltd.
Jingzhen Guo: Fudan University
Li Qin: Lifetech Scientific (Shenzhen) Co. Ltd.
Daokun Shi: Fudan University
Xiaoli Shi: Lifetech Scientific (Shenzhen) Co. Ltd.
Haifeng Li: Lifetech Scientific (Shenzhen) Co. Ltd.
Deyuan Zhang: Lifetech Scientific (Shenzhen) Co. Ltd.
Wei Guo: First Medical Center of Chinese PLA General Hospital
Jiandong Ding: Fudan University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract While chronic limb-threatening ischemia is a serious peripheral artery disease, the lack of an appropriate stent significantly limits the potential of interventional treatment. In spite of much progress in coronary stents, little is towards peripheral stents, which are expected to be both long and biodegradable and thus require a breakthrough in core techniques. Herein, we develop a long and biodegradable stent with a length of up to 118 mm based on a metal-polymer composite material. To achieve a well-prepared homogeneous coating on a long stent during ultrasonic spraying, a magnetic levitation is employed. In vivo degradation of the stent is investigated in rabbit abdominal aorta/iliac arteries, and its preclinical safety is evaluated in canine infrapopliteal arteries. First-in-man implantation of the stent is carried out in the below-the-knee artery. The 13 months’ follow-ups demonstrate the feasibility of the long and biodegradable stent in clinical applications.

Date: 2024
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DOI: 10.1038/s41467-024-52288-4

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