Rapid context inference in a thalamocortical model using recurrent neural networks

Wei-Long Zheng (), Zhongxuan Wu, Ali Hummos, Guangyu Robert Yang and Michael M. Halassa ()
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Wei-Long Zheng: Shanghai Jiao Tong University
Zhongxuan Wu: The University of Texas at Austin
Ali Hummos: Massachusetts Institute of Technology
Guangyu Robert Yang: Massachusetts Institute of Technology
Michael M. Halassa: Tufts University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Cognitive flexibility is a fundamental ability that enables humans and animals to exhibit appropriate behaviors in various contexts. The thalamocortical interactions between the prefrontal cortex (PFC) and the mediodorsal thalamus (MD) have been identified as crucial for inferring temporal context, a critical component of cognitive flexibility. However, the neural mechanism responsible for context inference remains unknown. To address this issue, we propose a PFC-MD neural circuit model that utilizes a Hebbian plasticity rule to support rapid, online context inference. Specifically, the model MD thalamus can infer temporal contexts from prefrontal inputs within a few trials. This is achieved through the use of PFC-to-MD synaptic plasticity with pre-synaptic traces and adaptive thresholding, along with winner-take-all normalization in the MD. Furthermore, our model thalamus gates context-irrelevant neurons in the PFC, thus facilitating continual learning. We evaluate our model performance by having it sequentially learn various cognitive tasks. Incorporating an MD-like component alleviates catastrophic forgetting of previously learned contexts and demonstrates the transfer of knowledge to future contexts. Our work provides insight into how biological properties of thalamocortical circuits can be leveraged to achieve rapid context inference and continual learning.

Date: 2024
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DOI: 10.1038/s41467-024-52289-3

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