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HASTY-mediated miRNA dynamics modulate nitrogen starvation-induced leaf senescence in Arabidopsis

Yasuhito Sakuraba, Mailun Yang and Shuichi Yanagisawa ()
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Yasuhito Sakuraba: The University of Tokyo, Yayoi 1-1-1
Mailun Yang: The University of Tokyo, Yayoi 1-1-1
Shuichi Yanagisawa: The University of Tokyo, Yayoi 1-1-1

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Nitrogen (N) deficiency responses are essential for plant survival and reproduction. Here, via an expression genome-wide association study (eGWAS), we reveal a mechanism that regulates microRNA (miRNA) dynamics necessary for N deficiency responses in Arabidopsis. Differential expression levels of three NAC transcription factor (TF) genes involved in leaf N deficiency responses among Arabidopsis accessions are most significantly associated with polymorphisms in HASTY (HST), which encodes an importin/exportin family protein responsible for the generation of mature miRNAs. HST acts as a negative regulator of N deficiency-induced leaf senescence, and the disruption and overexpression of HST differently modifies miRNA dynamics in response to N deficiency, altering levels of miRNAs targeting transcripts. Interestingly, N deficiency prevents the interaction of HST with HST-interacting proteins, DCL1 and RAN1, and some miRNAs. This suggests that HST-mediated regulation of miRNA dynamics collectively controls regulations mediated by multiple N deficiency response-associated NAC TFs, thereby being central to the N deficiency response network.

Date: 2024
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DOI: 10.1038/s41467-024-52339-w

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