Resolving the metabolism of monolignols and other lignin-related aromatic compounds in Xanthomonas citri

Damaris B. Martim, Anna J. V. C. Brilhante, Augusto R. Lima, Douglas A. A. Paixão, Joaquim Martins-Junior, Fernanda M. Kashiwagi, Lucia D. Wolf, Mariany S. Costa, Fabrícia F. Menezes, Rafaela Prata, Matheus C. Gazolla, Juliana A. Aricetti, Gabriela F. Persinoti, George J. M. Rocha and Priscila O. Giuseppe ()
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Damaris B. Martim: University of Campinas (UNICAMP)
Anna J. V. C. Brilhante: University of Campinas (UNICAMP)
Augusto R. Lima: University of Campinas (UNICAMP)
Douglas A. A. Paixão: Brazilian Center for Research in Energy and Materials (CNPEM)
Joaquim Martins-Junior: Brazilian Center for Research in Energy and Materials (CNPEM)
Fernanda M. Kashiwagi: Brazilian Center for Research in Energy and Materials (CNPEM)
Lucia D. Wolf: Brazilian Center for Research in Energy and Materials (CNPEM)
Mariany S. Costa: Brazilian Center for Research in Energy and Materials (CNPEM)
Fabrícia F. Menezes: Brazilian Center for Research in Energy and Materials (CNPEM)
Rafaela Prata: Brazilian Center for Research in Energy and Materials (CNPEM)
Matheus C. Gazolla: Brazilian Center for Research in Energy and Materials (CNPEM)
Juliana A. Aricetti: Brazilian Center for Research in Energy and Materials (CNPEM)
Gabriela F. Persinoti: Brazilian Center for Research in Energy and Materials (CNPEM)
George J. M. Rocha: Brazilian Center for Research in Energy and Materials (CNPEM)
Priscila O. Giuseppe: University of Campinas (UNICAMP)

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Lignin, a major plant cell wall component, has an important role in plant-defense mechanisms against pathogens and is a promising renewable carbon source to produce bio-based chemicals. However, our understanding of microbial metabolism is incomplete regarding certain lignin-related compounds like p-coumaryl and sinapyl alcohols. Here, we reveal peripheral pathways for the catabolism of the three main lignin precursors (p-coumaryl, coniferyl, and sinapyl alcohols) in the plant pathogen Xanthomonas citri. Our study demonstrates all the necessary enzymatic steps for funneling these monolignols into the tricarboxylic acid cycle, concurrently uncovering aryl aldehyde reductases that likely protect the pathogen from aldehydes toxicity. It also shows that lignin-related aromatic compounds activate transcriptional responses related to chemotaxis and flagellar-dependent motility, which might play an important role during plant infection. Together our findings provide foundational knowledge to support biotechnological advances for both plant diseases treatments and conversion of lignin-derived compounds into bio-based chemicals.

Date: 2024
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DOI: 10.1038/s41467-024-52367-6

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