Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression

Xin Huang, Chris Fowler, Yihan Li, Qiao-Xin Li, Jiaqi Sun, Yijun Pan, Liang Jin, Keyla A. Perez, Céline Dubois, Yen Y. Lim, Candace Drysdale, Rebecca L. Rumble, Holly R. Chinnery, Christopher C. Rowe, Ralph N. Martins, Paul Maruff, James D. Doecke, Yong Lin, Abdel A. Belaidi, Kevin J. Barnham, Colin L. Masters () and Ben J. Gu ()
Additional contact information
Xin Huang: The University of Melbourne
Chris Fowler: The University of Melbourne
Yihan Li: The University of Melbourne
Qiao-Xin Li: The University of Melbourne
Jiaqi Sun: The University of Melbourne
Yijun Pan: The University of Melbourne
Liang Jin: The University of Melbourne
Keyla A. Perez: The University of Melbourne
Céline Dubois: The University of Melbourne
Yen Y. Lim: Monash University
Candace Drysdale: The University of Melbourne
Rebecca L. Rumble: The University of Melbourne
Holly R. Chinnery: The University of Melbourne
Christopher C. Rowe: Austin Health
Ralph N. Martins: Edith Cowan University
Paul Maruff: The University of Melbourne
James D. Doecke: Australian E-Health Research Center, CSIRO
Yong Lin: Fudan University
Abdel A. Belaidi: The University of Melbourne
Kevin J. Barnham: The University of Melbourne
Colin L. Masters: The University of Melbourne
Ben J. Gu: The University of Melbourne

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay to identify Aβ-binding monocytes in blood, validated by confocal microscopy, Western blotting, and mass spectrometry. Flow cytometry immunophenotyping and correlation with AD biomarkers are studied in 150 participants from the AIBL study. We also examine monocytes in human cerebrospinal fluid (CSF) and their migration in an APP/PS1 mouse model. The assay reveals macrophage-like Aβ-binding monocytes with high phagocytic potential in both the periphery and CNS. We find lower surface Aβ levels in mild cognitive impairment (MCI) and AD-dementia patients compared to cognitively unimpaired individuals. Monocyte infiltration from blood to CSF and migration from CNS to peripheral lymph nodes and blood are observed. Here we show that Aβ-binding monocytes may play a role in CNS Aβ clearance, suggesting their potential as a biomarker for AD diagnosis and monitoring.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-52396-1 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52396-1

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-52396-1

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().