Post-COVID-19 condition symptoms among emergency department patients tested for SARS-CoV-2 infection

Patrick M. Archambault (), Rhonda J. Rosychuk, Martyne Audet, Jeffrey P. Hau, Lorraine Graves, Simon Décary, Jeffrey J. Perry, Steven C. Brooks, Laurie J. Morrison, Raoul Daoust, David Seonguk Yeom, Hana Wiemer, Patrick T. Fok, Andrew D. McRae, Kavish Chandra, Michelle E. Kho, Dawn Stacey, Bilkis Vissandjée, Matthew Menear, Eric Mercier, Samuel Vaillancourt, Samina Aziz, Dianne Zakaria, Phil Davis, Katie N. Dainty, Jean-Sébastien Paquette, Murdoch Leeies, Susie Goulding, Elyse Berger Pelletier and Corinne M. Hohl
Additional contact information
Patrick M. Archambault: Université Laval
Rhonda J. Rosychuk: University of Alberta
Martyne Audet: Centre intégré de santé et de services sociaux de Chaudière-Appalaches
Jeffrey P. Hau: The University of British Columbia
Lorraine Graves: The University of British Columbia
Simon Décary: Université de Sherbrooke
Jeffrey J. Perry: University of Ottawa
Steven C. Brooks: Queen’s University
Laurie J. Morrison: University of Toronto
Raoul Daoust: Université de Montréal
David Seonguk Yeom: The University of British Columbia
Hana Wiemer: Dalhousie University
Patrick T. Fok: Dalhousie University
Andrew D. McRae: University of Calgary
Kavish Chandra: Dalhousie Medicine New Brunswick
Michelle E. Kho: McMaster University
Dawn Stacey: Ottawa Hospital Research Institute
Bilkis Vissandjée: Université de Montréal
Matthew Menear: Université Laval
Eric Mercier: Université Laval
Samuel Vaillancourt: University of Toronto
Samina Aziz: Public Health Agency of Canada
Dianne Zakaria: Public Health Agency of Canada
Phil Davis: University of Saskatchewan
Katie N. Dainty: North York General Hospital
Jean-Sébastien Paquette: Université Laval
Murdoch Leeies: University of Manitoba
Susie Goulding: The University of British Columbia
Elyse Berger Pelletier: Université Laval
Corinne M. Hohl: The University of British Columbia

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Symptoms of the Post-COVID-19 Condition are often non-specific making it a challenge to distinguish them from symptoms due to other medical conditions. In this study, we compare the proportion of emergency department patients who developed symptoms consistent with the World Health Organization’s Post-COVID-19 Condition clinical case definition between those who tested positive for Severe Acute Respiratory Syndrome Coronavirus-2 infection and time-matched patients who tested negative. Our results show that over one-third of emergency department patients with a proven acute infection meet Post-COVID-19 Condition criteria 3 months post-index visit. However, one in five test-negative patients who claim never having been infected also report symptoms consistent with Post-COVID-19 Condition highlighting the lack of specificity of the clinical case definition. Testing for SARS-CoV-2 during the acute phase of a suspected infection should continue until specific biomarkers of Post-COVID-19 Condition become available for diagnosis and treatment.

Date: 2024
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DOI: 10.1038/s41467-024-52404-4

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