Highly-stable, injectable, conductive hydrogel for chronic neuromodulation

Ming Yang, Lufang Wang, Wenliang Liu, Wenlong Li, Yewei Huang, Qiaofeng Jin, Li Zhang (), Yuanwen Jiang () and Zhiqiang Luo ()
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Ming Yang: Huazhong University of Science and Technology
Lufang Wang: Huazhong University of Science and Technology
Wenliang Liu: Huazhong University of Science and Technology
Wenlong Li: Huazhong University of Science and Technology
Yewei Huang: University of Pennsylvania
Qiaofeng Jin: Huazhong University of Science and Technology
Li Zhang: Huazhong University of Science and Technology
Yuanwen Jiang: University of Pennsylvania
Zhiqiang Luo: Huazhong University of Science and Technology

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Electroceuticals, through the selective modulation of peripheral nerves near target organs, are promising for treating refractory diseases. However, the small sizes and the delicate nature of these nerves present challenges in simplifying the fixation and stabilizing the electrical-coupling interface for neural electrodes. Herein, we construct a robust neural interface for fine peripheral nerves using an injectable bio-adhesive hydrogel bioelectronics. By incorporating a multifunctional molecular regulator during network formation, we optimize the injectability and conductivity of the hydrogel through fine-tuning reaction kinetics and multi-scale interactions within the conductive network. Meanwhile, the mechanical and electrical stability of the hydrogel is achieved without compromising its injectability. Minimal tissue damage along with low and stable impedance of the injectable neural interface enables chronic vagus neuromodulation for myocardial infarction therapy in the male rat model. Our highly-stable, injectable, conductive hydrogel bioelectronics are readily available to target challenging anatomical locations, paving the way for future precision bioelectronic medicine.

Date: 2024
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DOI: 10.1038/s41467-024-52418-y

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