Cardiovascular and renal effects of apelin in chronic kidney disease: a randomised, double-blind, placebo-controlled, crossover study

Fiona A. Chapman, Vanessa Melville, Emily Godden, Beth Morrison, Lorraine Bruce, Janet J. Maguire, Anthony P. Davenport, David E. Newby and Neeraj Dhaun ()
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Fiona A. Chapman: University of Edinburgh
Vanessa Melville: University of Edinburgh
Emily Godden: University of Edinburgh
Beth Morrison: University of Edinburgh
Lorraine Bruce: University of Edinburgh
Janet J. Maguire: University of Cambridge
Anthony P. Davenport: University of Cambridge
David E. Newby: University of Edinburgh
Neeraj Dhaun: University of Edinburgh

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Chronic kidney disease (CKD) affects ~10% of the population and cardiovascular disease is its commonest complication. Despite treatment, patient outcomes remain poor and newer therapies are urgently needed. Here, we investigated the systemic and renal effects of apelin in CKD. In a randomized, double-blind, placebo-controlled, crossover study, 24 subjects (12 patients with CKD and 12 matched healthy subjects) received pyroglutamated apelin-13 ([Pyr1]apelin-13, 1 nmol/min and 30 nmol/min) or matched placebo on two separate visits. Systemic and renal hemodynamics were monitored throughout. The co-primary endpoints were change in systemic vascular resistance index and renal blood flow. Secondary endpoints were change in blood pressure, cardiac output, pulse wave velocity, glomerular filtration rate, natriuresis, free water clearance and urinary protein excretion. In both health and CKD, 30 nmol/min [Pyr1]apelin-13 reduced mean arterial pressure by ~4%, systemic vascular resistance by ~12%, and increased cardiac index by ~10%, compared to placebo (p

Date: 2024
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DOI: 10.1038/s41467-024-52447-7

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