Strategically engineered Au(I) complexes for orchestrated tumor eradication via chemo-phototherapy and induced immunogenic cell death

Na Feng, Zhen Peng, Xin Zhang, Yiling Lin, Lianrui Hu (), Lei Zheng (), Ben Zhong Tang () and Jing Zhang ()
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Na Feng: Southern Medical University
Zhen Peng: Central China Normal University
Xin Zhang: East China Normal University
Yiling Lin: Southern Medical University
Lianrui Hu: East China Normal University
Lei Zheng: Southern Medical University
Ben Zhong Tang: The Chinese University of Hong Kong
Jing Zhang: Southern Medical University

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Cancer is a significant cause of death around the world, and for many varieties, treatment is not successful. Therefore, there is a need for the development of innovative, efficacious, and precisely targeted treatments. Here, we develop a series of Au(I) complexes (1-4) through rational manipulation of ligand structures, thereby achieving tumor cell specific targeting and orchestrated tumor eradication via chemo-phototherapy and induced immunogenic cell death. A comprehensive exploration based on in vitro and in vivo female mice experimentation shows that complex 4 exhibits proficiency in specific tumor imaging, endoplasmic reticulum targeting, and has robust therapeutic capabilities. Mechanistic elucidation indicates that the anticancer effect derives from the synergistic actions of thioredoxin reductase inhibition, highly efficient reactive oxygen species production and immunogenic cell death. This work presents a report on a robust Au(I) complex integrating three therapeutic modalities within a singular system. The strategy presented in this work provides a valuable reference for the development of high-performance therapeutic agents.

Date: 2024
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DOI: 10.1038/s41467-024-52458-4

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