Impact of pneumococcal conjugate vaccines on invasive pneumococcal disease-causing lineages among South African children

Cebile Lekhuleni (), Kedibone Ndlangisa, Rebecca A. Gladstone, Sopio Chochua, Benjamin J. Metcalf, Yuan Li, Jackie Kleynhans, Linda Gouveia, Scott Hazelhurst, Ana D. S. Ferreira, Happy Skosana, Sibongile Walaza, Vanessa Quan, Susan Meiring, Paulina A. Hawkins, Lesley McGee, Stephen D. Bentley, Cheryl Cohen, Stephanie W. Lo, Anne Gottberg and Mignon Plessis
Additional contact information
Cebile Lekhuleni: a division of the National Health Laboratory Service
Kedibone Ndlangisa: a division of the National Health Laboratory Service
Rebecca A. Gladstone: University of Oslo
Sopio Chochua: Centers for Disease Control and Prevention
Benjamin J. Metcalf: Centers for Disease Control and Prevention
Yuan Li: Centers for Disease Control and Prevention
Jackie Kleynhans: a division of the National Health Laboratory Service
Linda Gouveia: a division of the National Health Laboratory Service
Scott Hazelhurst: University of the Witwatersrand
Ana D. S. Ferreira: Wellcome Genome Campus
Happy Skosana: a division of the National Health Laboratory Service
Sibongile Walaza: a division of the National Health Laboratory Service
Vanessa Quan: A division of the National Health Laboratory Service
Susan Meiring: A division of the National Health Laboratory Service
Paulina A. Hawkins: Centers for Disease Control and Prevention
Lesley McGee: Centers for Disease Control and Prevention
Stephen D. Bentley: Wellcome Genome Campus
Cheryl Cohen: a division of the National Health Laboratory Service
Stephanie W. Lo: Wellcome Genome Campus
Anne Gottberg: a division of the National Health Laboratory Service
Mignon Plessis: a division of the National Health Laboratory Service

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Invasive pneumococcal disease (IPD) due to non-vaccine serotypes after the introduction of pneumococcal conjugate vaccines (PCV) remains a global concern. This study used pathogen genomics to evaluate changes in invasive pneumococcal lineages before, during and after vaccine introduction in South Africa. We included genomes (N = 3104) of IPD isolates from individuals aged

Date: 2024
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DOI: 10.1038/s41467-024-52459-3

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