Structural basis of ligand recognition and activation of the histamine receptor family

Xuan Zhang (), Guibing Liu, Ya-Ni Zhong, Ru Zhang, Chuan-Cheng Yang, Canyang Niu, Xuanyu Pu, Jingjing Sun, Tianyao Zhang, Lejin Yang, Chao Zhang, Xiu Li, Xinyuan Shen, Peng Xiao (), Jin-Peng Sun () and Weimin Gong ()
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Xuan Zhang: University of Science and Technology of China
Guibing Liu: University of Science and Technology of China
Ya-Ni Zhong: Shandong University
Ru Zhang: Shandong University
Chuan-Cheng Yang: Shandong University
Canyang Niu: Shandong University
Xuanyu Pu: Shandong University
Jingjing Sun: Shandong University
Tianyao Zhang: Shandong University
Lejin Yang: Shandong University
Chao Zhang: Shandong University
Xiu Li: University of Science and Technology of China
Xinyuan Shen: University of Science and Technology of China
Peng Xiao: Shandong University
Jin-Peng Sun: Shandong University
Weimin Gong: University of Science and Technology of China

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Histamine is a biogenic amine that is critical in various physiological and pathophysiological processes, including but not limited to allergic reactions, wakefulness, gastric acid secretion and neurotransmission. Here, we determine 9 cryo-electron microscopy (cryo-EM) structures of the 4 histamine receptors in complex with four different G protein subtypes, with endogenous or synthetic agonists bound. Inside the ligand pocket, we identify key motifs for the recognition of histamine, the distinct binding orientations of histamine and three subpockets that facilitate the design of specific ligands. In addition, we also identify key residues responsible for the selectivity of immethridine. Moreover, we reveal distinct structural features as determinants of Gq vs. Gs or Gs vs. Gi coupling differences among the histamine receptors. Our study provides a structural framework for understanding the ligand recognition and G protein coupling of all 4 histamine receptors, which may facilitate the rational design of ligands targeting these receptors.

Date: 2024
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DOI: 10.1038/s41467-024-52585-y

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