Selective regulation of macrophage lipid metabolism via nanomaterials’ surface chemistry

Junguang Wu, Xuan Bai, Liang Yan, Didar Baimanov, Yalin Cong, Peiyu Quan, Rui Cai, Yong Guan, Wei Bu, Binhua Lin, Jing Wang, Shengtao Yu, Shijiao Li, Yu Chong, Yang Li, Guoqing Hu, Yuliang Zhao, Chunying Chen () and Liming Wang ()
Additional contact information
Junguang Wu: National Center for Nanoscience and Technology of China
Xuan Bai: Zhejiang University
Liang Yan: National Center for Nanoscience and Technology of China
Didar Baimanov: National Center for Nanoscience and Technology of China
Yalin Cong: National Center for Nanoscience and Technology of China
Peiyu Quan: National Center for Nanoscience and Technology of China
Rui Cai: National Center for Nanoscience and Technology of China
Yong Guan: University of Science and Technology of China
Wei Bu: The University of Chicago
Binhua Lin: The University of Chicago
Jing Wang: Peking University
Shengtao Yu: National Center for Nanoscience and Technology of China
Shijiao Li: National Center for Nanoscience and Technology of China
Yu Chong: Soochow University
Yang Li: Chinese Academy of Sciences
Guoqing Hu: Zhejiang University
Yuliang Zhao: National Center for Nanoscience and Technology of China
Chunying Chen: National Center for Nanoscience and Technology of China
Liming Wang: National Center for Nanoscience and Technology of China

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Understanding the interface between nanomaterials and lipoproteins is crucial for gaining insights into their impact on lipoprotein structure and lipid metabolism. Here, we use graphene oxide (GOs) nanosheets as a controlled carbon nanomaterial model to study how surface properties influence lipoprotein corona formation and show that GOs have strong binding affinity with low-density lipoprotein (LDL). We use advanced techniques including X-ray reflectivity, circular dichroism, and molecular simulations to explore the interfacial interactions between GOs and LDL. Specifically, hydrophobic GOs preferentially associate with LDL’s lipid components, whereas hydrophilic GOs tend to bind with apolipoproteins. Furthermore, these GOs distinctly modulate a variety of lipid metabolism pathways, including LDL recognition, uptake, hydrolysis, efflux, and lipid droplet formation. This study underscores the importance of structure analysis at the nano-biomolecule interface, emphasizing how nanomaterials’ surface properties critically influence cellular lipid metabolism. These insights will inspire the design and application of future biocompatible nanomaterials and nanomedicines.

Date: 2024
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DOI: 10.1038/s41467-024-52609-7

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