Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

Jasper Panten, Stefania Prete, James P. Cleland, Lauren M. Saunders, Job Riet, Anja Schneider, Paul Ginno, Nina Schneider, Marie-Luise Koch, Xuqi Chen, Moritz Gerstung, Oliver Stegle, Arthur P. Arnold, James M. A. Turner, Edith Heard () and Duncan T. Odom ()
Additional contact information
Jasper Panten: German Cancer Research Center (DKFZ)
Stefania Prete: German Cancer Research Center (DKFZ)
James P. Cleland: German Cancer Research Center (DKFZ)
Lauren M. Saunders: German Cancer Research Center (DKFZ)
Job Riet: German Cancer Research Center (DKFZ)
Anja Schneider: German Cancer Research Center (DKFZ)
Paul Ginno: German Cancer Research Center (DKFZ)
Nina Schneider: German Cancer Research Center (DKFZ)
Marie-Luise Koch: German Cancer Research Center (DKFZ)
Xuqi Chen: University of California
Moritz Gerstung: German Cancer Research Center (DKFZ)
Oliver Stegle: German Cancer Research Center (DKFZ)
Arthur P. Arnold: University of California
James M. A. Turner: The Francis Crick Institute
Edith Heard: European Molecular Biology Laboratory (EMBL)
Duncan T. Odom: German Cancer Research Center (DKFZ)

Nature Communications, 2024, vol. 15, issue 1, 1-8

Abstract: Abstract The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.

Date: 2024
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DOI: 10.1038/s41467-024-52640-8

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