Engineering tunable catch bonds with DNA

Micah Yang, David t. R. Bakker and Isaac T. S. Li ()
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Micah Yang: The University of British Columbia
David t. R. Bakker: The University of British Columbia
Isaac T. S. Li: The University of British Columbia

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Unlike most adhesive bonds, biological catch bonds strengthen with increased tension. This characteristic is essential to specific receptor-ligand interactions, underpinning biological adhesion dynamics, cell communication, and mechanosensing. While artificial catch bonds have been conceived, the tunability of their catch behaviour is limited. Here, we present the fish-hook, a rationally designed DNA catch bond that can be finely adjusted to a wide range of catch behaviours. We develop models to design these DNA structures and experimentally validate different catch behaviours by single-molecule force spectroscopy. The fish-hook architecture supports a vast sequence-dependent behaviour space, making it a valuable tool for reprogramming biological interactions and engineering force-strengthening materials.

Date: 2024
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DOI: 10.1038/s41467-024-52749-w

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