Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers

Yuan Chen, Li Zhang, Xingjie Wu, Xuecheng Sun, Noah R. Sundah, Chi Yan Wong, Auginia Natalia, John K. C. Tam, Darren Wan-Teck Lim, Balram Chowbay, Beng Ti Ang, Carol Tang, Tze Ping Loh and Huilin Shao ()
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Yuan Chen: National University of Singapore
Li Zhang: National University of Singapore
Xingjie Wu: National University of Singapore
Xuecheng Sun: National University of Singapore
Noah R. Sundah: National University of Singapore
Chi Yan Wong: National University of Singapore
Auginia Natalia: National University of Singapore
John K. C. Tam: National University of Singapore
Darren Wan-Teck Lim: National Cancer Centre Singapore
Balram Chowbay: Duke-NUS Medical School
Beng Ti Ang: National Neuroscience Institute
Carol Tang: National Neuroscience Institute
Tze Ping Loh: National University of Singapore
Huilin Shao: National University of Singapore

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Conventional magnetic biosensing technologies have reduced analytical capacity for magnetic field dimensionality and require extensive sample processing. To address these challenges, we spatially engineer 3D magnetic response gradients for direct and programmable molecular detection in native biofluids. Named magnetic augmentation through triple-gradient coupling for high-performance detection (MATCH), the technology comprises gradient-distributed magnetic nanoparticles encapsulated within responsive hydrogel pillars and suspended above a magnetic sensor array. This configuration enables multi-gradient matching to achieve optimal magnetic activation, response and transduction, respectively. Through focused activation by target biomarkers, the platform preferentially releases sensor-proximal nanoparticles, generating response gradients that complement the sensor’s intrinsic detection capability. By implementing an upstream module that recognizes different biomarkers and releases universal activation molecules, the technology achieves programmable detection of various circulating biomarkers in native plasma. It bypasses conventional magnetic labeling, completes in

Date: 2024
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DOI: 10.1038/s41467-024-52754-z

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