The activating receptor NKG2D is an anti-fungal pattern recognition receptor

Yoav Charpak-Amikam, Mark Kournos, Rebecca Kotzur, Batya Isaacson, Tal Bagad Brenner, Elidet Gomez-Cesar, Ammar Abou-Kandil, Ronen Ben-Ami, Maya Korem, Nadia Guerra, Nir Osherov and Ofer Mandelboim ()
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Yoav Charpak-Amikam: IMRIC
Mark Kournos: IMRIC
Rebecca Kotzur: IMRIC
Batya Isaacson: IMRIC
Tal Bagad Brenner: IMRIC
Elidet Gomez-Cesar: IMRIC
Ammar Abou-Kandil: Ramat-Aviv
Ronen Ben-Ami: Tel Aviv University
Maya Korem: Hadassah-Hebrew University Medical Center
Nadia Guerra: Imperial College London
Nir Osherov: Ramat-Aviv
Ofer Mandelboim: IMRIC

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract NKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8+ T cells. The known role of NKG2D is to recognize a family of self-induced stress ligands that are upregulated on stressed cells such as cancerous or virally infected cells. Fungal pathogens are a major threat to human health, infecting more than a billion patients yearly and becoming more common and drug resistant. Here we show that NKG2D plays a critical role in the immune response against fungal infections. NKG2D can recognize fungal pathogens from most major families including Candida, Cryptococcus and Aspergillus species, and mice lacking NKG2D are extremely sensitive to fungal infections in models of both invasive and mucosal infections, making NKG2D an anti-fungal pattern recognition receptor.

Date: 2024
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DOI: 10.1038/s41467-024-52913-2

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