AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off

Zhen Wang (), Xiaofan Zhang, Chunyan Liu, Susan Duncan, Runlai Hang, Jing Sun, Lilan Luo, Yiliang Ding and Xiaofeng Cao ()
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Zhen Wang: Chinese Academy of Sciences
Xiaofan Zhang: Chinese Academy of Sciences
Chunyan Liu: Chinese Academy of Sciences
Susan Duncan: Norwich Research Park
Runlai Hang: Chinese Academy of Sciences
Jing Sun: Chinese Academy of Sciences
Lilan Luo: Chinese Academy of Sciences
Yiliang Ding: Norwich Research Park
Xiaofeng Cao: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Translation, a fundamental process regulating cellular growth and proliferation, relies on functional ribosomes. As sessile organisms, plants have evolved adaptive strategies to maintain a delicate balance between growth and stress response. But the underlying mechanisms, particularly on the translational level, remain less understood. In this study, we revealed the mechanisms of AtPRMT3-RPS2B in orchestrating ribosome assembly and managing translational regulation. Through a forward genetic screen, we identified PDCD2-D1 as a suppressor gene restoring abnormal development and ribosome biogenesis in atprmt3-2 mutants. Our findings confirmed that PDCD2 interacts with AtPRMT3-RPS2B, and facilitates pre-ribosome transport through nuclear pore complex, finally ensuring normal ribosome translation in the cytoplasm. Additionally, the dysfunction of AtPRMT3-RPS2B was found to enhance freezing tolerance. Moreover, we revealed that AtPRMT3-RPS2B promotes the translation of housekeeping mRNAs while concurrently repressing stress-related mRNAs. In summary, our study sheds light on the regulatory roles of AtPRMT3-RPS2B in ribosome assembly and translational balance, enabling the trade-off between growth and stress.

Date: 2024
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DOI: 10.1038/s41467-024-52945-8

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