Glycerophospholipid remodeling is critical for orthoflavivirus infection

Julia Hehner, Laura Schneider, Anna Woitalla, Benjamin Ott, Kim Chi Thi Vu, Anja Schöbel, Torsten Hain, Dominik Schwudke () and Eva Herker ()
Additional contact information
Julia Hehner: University of Marburg
Laura Schneider: University of Marburg
Anna Woitalla: Research Center Borstel – Leibniz Lung Center
Benjamin Ott: Justus Liebig University Giessen
Kim Chi Thi Vu: University of Marburg
Anja Schöbel: University of Marburg
Torsten Hain: Justus Liebig University Giessen
Dominik Schwudke: Research Center Borstel – Leibniz Lung Center
Eva Herker: University of Marburg

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile, and tick-borne encephalitis virus, as well as dengue and yellow fever virus. Early in infection specific lipids accumulate, e.g., neutral lipids in Zika and some lysophospholipids in all infections. Ceramide levels increase following infection with viruses that cause a cytopathic effect. In addition, fatty acid desaturation as well as glycerophospholipid metabolism are significantly altered. Importantly, depletion of enzymes involved in phosphatidylserine metabolism as well as phosphatidylinositol biosynthesis reduce orthoflavivirus titers and cytopathic effects while inhibition of fatty acid monounsaturation only rescues from virus-induced cell death. Interestingly, interfering with ceramide synthesis has opposing effects on virus replication and cytotoxicity depending on the targeted enzyme. Thus, lipid remodeling by orthoflaviviruses includes distinct changes but also common patterns shared by several viruses that are needed for efficient infection and replication.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-52979-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-52979-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-52979-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().