Deciphering mouse brain spatial diversity via glyco-lipidomic mapping

Jua Lee, Dongtan Yin, Jaekyung Yun, Minsoo Kim, Seong-Wook Kim, Heeyoun Hwang, Ji Eun Park, Boyoung Lee, C. Justin Lee, Hee-Sup Shin and Hyun Joo An ()
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Jua Lee: Northwestern University
Dongtan Yin: Chungnam National University
Jaekyung Yun: Chungnam National University
Minsoo Kim: Institute for Basic Science
Seong-Wook Kim: Institute for Basic Science
Heeyoun Hwang: Korea Basic Science Institute
Ji Eun Park: Chungnam National University
Boyoung Lee: Institute for Basic Science
C. Justin Lee: Institute for Basic Science
Hee-Sup Shin: Institute for Basic Science
Hyun Joo An: Chungnam National University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Gangliosides in the brain play a crucial role in modulating the integrity of vertebrate central nervous system in a region-specific manner. However, to date, a comprehensive structural elucidation of complex intact ganglioside isomers has not been achieved, resulting in the elusiveness into related molecular mechanism. Here, we present a glycolipidomic approach for isomer-specific and brain region-specific profiling of the mouse brain. Considerable region-specificity and commonality in specific group of regions are highlighted. Notably, we observe a similarity in the abundance of major isomers, GD1a and GD1b, within certain regions, which provides significant biological implications with interpretation through the lens of a theoretical retrosynthetic state-transition network. Furthermore, A glycocentric-omics approaches using gangliosides and N-glycans reveal a remarkable convergence in spatial dynamics, providing valuable insight into molecular interaction network. Collectively, this study uncovers the spatial dynamics of intact glyco-conjugates in the brain, which are relevant to regional function and accelerates the discovery of potential therapeutic targets for brain diseases.

Date: 2024
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DOI: 10.1038/s41467-024-53032-8

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