Innovative approaches in phenotypic beta-lactamase detection for personalised infection management

Jennifer Lawrence (), Danny O’Hare, Joseph Batenburg-Sherwood, Mark Sutton, Alison Holmes and Timothy Miles Rawson
Additional contact information
Jennifer Lawrence: Hammersmith Campus
Danny O’Hare: Imperial College London
Joseph Batenburg-Sherwood: White City Campus
Mark Sutton: Porton Down
Alison Holmes: Hammersmith Campus
Timothy Miles Rawson: Hammersmith Campus

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Beta-lactamase-producing Enterobacteriaceae present a significant therapeutic challenge. Current developments in phenotypic diagnostics focus primarily on rapid minimum inhibitory concentration (MIC) determination. There is a requirement for rapid phenotypic diagnostics to improve antimicrobial susceptibility tests (AST) and aid prescribing decisions. Phenotypic AST are limited in their ability to characterise beta-lactamase-producing Enterobacteriaceae in detail. Despite advances in rapid AST, gaps and opportunities remain for developing additional diagnostic approaches that facilitate personalised antimicrobial prescribing. In this perspective, we highlight the state-of-the-art in beta-lactamase detection, identify gaps in current practice, and discuss barriers for innovation within this field.

Date: 2024
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DOI: 10.1038/s41467-024-53192-7

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