Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity

Marina A. Schapfl, Gina M. LoMastro, Vincent Z. Braun, Maretoshi Hirai, Michelle S. Levine, Eva Kiermaier, Verena Labi, Andrew J. Holland and Andreas Villunger ()
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Marina A. Schapfl: Medical University of Innsbruck
Gina M. LoMastro: Johns Hopkins University School of Medicine
Vincent Z. Braun: Medical University of Innsbruck
Maretoshi Hirai: Kansai Medical University
Michelle S. Levine: Johns Hopkins University School of Medicine
Eva Kiermaier: University of Bonn
Verena Labi: Medical University of Innsbruck
Andrew J. Holland: Johns Hopkins University School of Medicine
Andreas Villunger: Medical University of Innsbruck

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Centrioles define centrosome structure and function. Deregulation of centriole numbers can cause developmental defects and cancer. The p53 tumor suppressor limits the growth of cells lacking or harboring additional centrosomes and can be engaged by the “mitotic surveillance” or the “PIDDosome pathway”, respectively. Here, we show that early B cell progenitors frequently present extra centrioles, ensuing their high proliferative activity and related DNA damage. Extra centrioles are efficiently cleared during B cell maturation. In contrast, centriole loss upon Polo-like kinase 4 (Plk4) deletion causes apoptosis and arrests B cell development. This defect can be rescued by co-deletion of Usp28, a critical component of the mitotic surveillance pathway, that restores cell survival and maturation. Centriole-deficient mature B cells are proliferation competent and mount a humoral immune response. Our findings imply that progenitor B cells are intolerant to centriole loss but permissive to centriole amplification, a feature potentially facilitating their malignant transformation.

Date: 2024
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DOI: 10.1038/s41467-024-53222-4

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