The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3

Zhuo Han, Rui Wang, Pengliang Chi, Zihan Zhang, Ling Min, Haizhan Jiao, Guojin Ou, Dan Zhou, Dandan Qin, Chengpeng Xu, Zheng Gao, Qianqian Qi, Jialu Li, Yuechao Lu, Xiang Wang, Jing Chen, Xingjiang Yu, Hongli Hu, Lei Li () and Dong Deng ()
Additional contact information
Zhuo Han: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
Rui Wang: Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
Pengliang Chi: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
Zihan Zhang: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
Ling Min: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
Haizhan Jiao: School of Medicine, The Chinese University of Hong Kong (Shenzhen)
Guojin Ou: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
Dan Zhou: Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
Dandan Qin: Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
Chengpeng Xu: Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
Zheng Gao: Center for Reproductive Medicine, The Third Affiliated Hospital of Guangzhou Medical University
Qianqian Qi: West China Second University Hospital, Sichuan University
Jialu Li: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
Yuechao Lu: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
Xiang Wang: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University
Jing Chen: Department of Pediatric Surgery, West China Hospital, Sichuan University
Xingjiang Yu: Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
Hongli Hu: School of Medicine, The Chinese University of Hong Kong (Shenzhen)
Lei Li: Key Laboratory of Organ Regeneration and Reconstruction, UCAS/IOZ/CAS
Dong Deng: State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract The subcortical maternal complex (SCMC) is essential for safeguarding female fertility in mammals. Assembled in oocytes, the SCMC maintains the cleavage of early embryos, but the underlying mechanism remains unclear. Here, we report that 14-3-3, a multifunctional protein, is a component of the SCMC. By resolving the structure of the 14-3-3-containing SCMC, we discover that phosphorylation of TLE6 contributes to the recruitment of 14-3-3. Mechanistically, during maternal-to-embryo transition, the SCMC stabilizes 14-3-3 protein and contributes to the proper control of CDC25B, thus ensuring the activation of the maturation-promoting factor and mitotic entry in mouse zygotes. Notably, the SCMC establishes a conserved molecular link with 14-3-3 and CDC25B in human oocytes/embryos. This study discloses the molecular mechanism through which the SCMC regulates the cell cycle in early embryos and elucidates the function of the SCMC in mammalian early embryogenesis.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-53277-3 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53277-3

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-53277-3

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().