A tissue bandage for pelvic ganglia injury

Jing He, Lin Qian, Zhuang Li, Yanpeng Wang, Kai Liu, Haibin Wei, Yuan Sun, Jiaoyan He, Ke Yao, Jiahao Weng, Xuanhan Hu, Dahong Zhang () and Yong He ()
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Jing He: Zhejiang University
Lin Qian: Hangzhou Medical College
Zhuang Li: Zhejiang University
Yanpeng Wang: Hangzhou Medical College
Kai Liu: Zhejiang University
Haibin Wei: Hangzhou Medical College
Yuan Sun: Zhejiang University
Jiaoyan He: Jinzhou Medical University
Ke Yao: Zhejiang University
Jiahao Weng: Zhejiang University
Xuanhan Hu: Hangzhou Medical College
Dahong Zhang: Hangzhou Medical College
Yong He: Zhejiang University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Neurogenic bladder often occurs after pelvic ganglia injury. Its symptoms, like severe urinary retention and incontinence, have a significant impact on individuals’ quality of life. Unfortunately, there are currently no effective treatments available for this type of injury. Here, we designed a fiber-enhanced tissue bandage for injured pelvic ganglia. Tight junctions formed in tissue bandages create a mini tissue structure that enhances resistance in an in vivo environment and delivers growth factors to support the healing of ganglia. Strength fibers are similar to clinical bandages and guarantee ease of handling. Furthermore, tissue bandages can be stored at low temperatures over 5 months without compromising cell viability, meeting the requirements for clinical products. A tissue bandage was applied to a male rat with a bilateral major pelvic ganglia crush injury. Compared to the severe neurogenic bladder symptoms observed in the injury and scaffold groups, tissue bandages significantly improved bladder function. We found that tissue bandage increases resistance to mechanical injury by boosting the expression of cytoskeletal proteins within the major pelvic ganglia. Overall, tissue bandages show promise as a practical therapeutic approach for ganglia repair, offering hope for developing more effective treatments for this thorny condition.

Date: 2024
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DOI: 10.1038/s41467-024-53302-5

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