Gustatory interface for operative assessment and taste decoding in patients with tongue cancer

Xiner Wang, Guo Bai, Jizhi Liang, Qianyang Xie, Zhaohan Chen, Erda Zhou, Meng Li, Xiaoling Wei, Liuyang Sun, Zhiyuan Zhang, Chi Yang (), Tiger H. Tao () and Zhitao Zhou ()
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Xiner Wang: Chinese Academy of Sciences
Guo Bai: Chinese Academy of Medical Sciences
Jizhi Liang: Chinese Academy of Sciences
Qianyang Xie: Chinese Academy of Medical Sciences
Zhaohan Chen: Neuroxess Co. Ltd
Erda Zhou: Chinese Academy of Sciences
Meng Li: University of Chinese Academy of Sciences
Xiaoling Wei: University of Chinese Academy of Sciences
Liuyang Sun: Chinese Academy of Sciences
Zhiyuan Zhang: Chinese Academy of Medical Sciences
Chi Yang: Chinese Academy of Medical Sciences
Tiger H. Tao: Chinese Academy of Sciences
Zhitao Zhou: University of Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Taste, a pivotal sense modality, plays a fundamental role in discerning flavors and evaluating the potential harm of food, thereby contributing to human survival, physical and mental health. Patients with tongue cancer may experience a loss of taste following extensive surgical resection with flap reconstruction. Here, we designed a gustatory interface that enables the non-invasive detection of tongue electrical activities for a comprehensive operative assessment. Moreover, it decodes gustatory information from the reconstructed tongue without taste buds. Our gustatory interface facilitates the recording and analysis of electrical activities on the tongue, yielding an electrical mapping across the entire tongue surface, which delineates the safe margin for surgical management and assesses flap viability for postoperative structure monitoring and prompt intervention. Furthermore, the gustatory interface helps patients discern tastes with an accuracy of 97.8%. Our invention offers a promising approach to clinical assessment and management and holds potential for improving the quality of life for individuals with tongue cancer.

Date: 2024
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DOI: 10.1038/s41467-024-53379-y

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