Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline

Yeongjun Jang, Livia Tomasini, Taejeong Bae, Anna Szekely, Flora M. Vaccarino () and Alexej Abyzov ()
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Yeongjun Jang: Mayo Clinic
Livia Tomasini: Yale University
Taejeong Bae: Mayo Clinic
Anna Szekely: Yale University
Flora M. Vaccarino: Yale University
Alexej Abyzov: Mayo Clinic

Nature Communications, 2024, vol. 15, issue 1, 1-8

Abstract: Abstract Little is known about the origin of germ cells in humans. We previously leveraged post-zygotic mutations to reconstruct zygote-rooted cell lineage ancestry trees in a phenotypically normal woman, termed NC0. Here, by sequencing the genome of her children and their father, we analyze the transmission of early pre-gastrulation lineages and corresponding mutations across human generations. We find that the germline in NC0 is polyclonal and is founded by at least two cells likely descending from the two blastomeres arising from the first zygotic cleavage. Analyzes of public data from several multi-children families and from 1934 familial quads confirm this finding in larger cohorts, revealing that known imbalances of up to 90:10 in early lineages allocation in somatic tissues are not reflected in mutation transmission to offspring, establishing a fundamental difference in lineage allocation between the soma and the germline. Analyzes of all the data consistently suggest that the germline has a balanced 50:50 lineage allocation from the first two blastomeres.

Date: 2024
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DOI: 10.1038/s41467-024-53485-x

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