Epicardial transplantation of antioxidant polyurethane scaffold based human amniotic epithelial stem cell patch for myocardial infarction treatment

Jinying Li, Yuejun Yao, Jiayi Zhou, Zhuoheng Yang, Chen Qiu, Yuwen Lu, Jieqi Xie, Jia Liu, Tuoying Jiang, Yaohui Kou, Zhen Ge, Ping Liang, Cong Qiu, Liyin Shen, Yang Zhu (), Changyou Gao () and Luyang Yu ()
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Jinying Li: Zhejiang University
Yuejun Yao: Zhejiang University
Jiayi Zhou: Zhejiang University
Zhuoheng Yang: Zhejiang University
Chen Qiu: Zhejiang University
Yuwen Lu: Zhejiang University
Jieqi Xie: Zhejiang University
Jia Liu: Zhejiang University
Tuoying Jiang: Zhejiang University
Yaohui Kou: Zhejiang University
Zhen Ge: Hangzhou Medical College
Ping Liang: Zhejiang University
Cong Qiu: Zhejiang University
Liyin Shen: Zhejiang University
Yang Zhu: Zhejiang University
Changyou Gao: Zhejiang University
Luyang Yu: Zhejiang University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Myocardial infarction (MI) is a leading cause of death globally. Stem cell therapy is considered a potential strategy for MI treatment. Transplantation of classic stem cells including embryonic, induced pluripotent and cardiac stem cells exhibited certain repairing effect on MI via supplementing cardiomyocytes, however, their clinical applications were blocked by problems of cell survival, differentiation, functional activity and also biosafety and ethical concerns. Here, we introduced human amniotic epithelial stem cells (hAESCs) featured with immunomodulatory activities, immune-privilege and biosafety, for constructing a stem cell cardiac patch based on porous antioxidant polyurethane (PUR), which demonstrated decent hAESCs compatibility. In rats, the administration of PUR-hAESC patch significantly reduced fibrosis and facilitated vascularization in myocardium after MI and consequently improved cardiac remodeling and function. Mechanistically, the patch provides a beneficial microenvironment for cardiac repair by facilitating a desirable immune response, paracrine modulation and limited oxidative milieu. Our findings may provide a potential therapeutic strategy for MI.

Date: 2024
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DOI: 10.1038/s41467-024-53531-8

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