A wearable and stretchable dual-wavelength LED device for home care of chronic infected wounds

Ming Li, Chenxi Wang, Qiang Yu, Haoyi Chen, Yingying Ma, Li Wei, Mei X. Wu (), Min Yao () and Min Lu ()
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Ming Li: Shanghai Jiao Tong University School of Medicine
Chenxi Wang: Shanghai Jiao Tong University School of Medicine
Qiang Yu: Shanghai Jiao Tong University School of Medicine
Haoyi Chen: Shanghai Jiao Tong University School of Medicine
Yingying Ma: Shanghai Jiao Tong University School of Medicine
Li Wei: Shanghai Jiao Tong University School of Medicine
Mei X. Wu: Harvard Medical School
Min Yao: Shanghai Jiao Tong University School of Medicine
Min Lu: Shanghai Jiao Tong University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-20

Abstract: Abstract Phototherapy can offer a safe and non-invasive solution against infections, while promoting wound healing. Conventional phototherapeutic devices are bulky and limited to hospital use. To overcome these challenges, we developed a wearable, flexible red and blue LED (r&bLED) patch controlled by a mobile-connected system, enabling safe self-application at home. The patch exhibits excellent skin compatibility, flexibility, and comfort, with high safety under system supervision. Additionally, we synthesized a sprayable fibrin gel (F-gel) containing blue light-sensitive thymoquinone and red light-synergistic NADH. Combined with bLED, thymoquinone eradicated microbes and biofilms within minutes, regardless of antibiotic resistance. Furthermore, NADH and rLED synergistically improved macrophage and endothelial cell mitochondrial function, promoting wound healing, reducing inflammation, and enhancing angiogenesis, as validated in infected diabetic wounds in mice and minipigs. This innovative technology holds great promise for revolutionizing at-home phototherapy for chronic infected wounds.

Date: 2024
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DOI: 10.1038/s41467-024-53579-6

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