Genome-wide meta-analysis of myasthenia gravis uncovers new loci and provides insights into polygenic prediction

Alice Braun, Sudhanshu Shekhar, Daniel F. Levey, Peter Straub, Julia Kraft, Georgia M. Panagiotaropoulou, Karl Heilbron, Swapnil Awasthi, Rafael Meleka Hanna, Sarah Hoffmann, Maike Stein, Sophie Lehnerer, Philipp Mergenthaler, Abdelrahman G. Elnahas, Apostolia Topaloudi, Maria Koromina, Teemu Palviainen, Bergrun Asbjornsdottir, Hreinn Stefansson, Astros Th. Skuladóttir, Ingileif Jónsdóttir, Kari Stefansson, Kadri Reis, Tõnu Esko, Aarno Palotie, Frank Leypoldt, Murray B. Stein, Pierre Fontanillas, Jaakko Kaprio, Joel Gelernter, Lea K. Davis, Peristera Paschou, Martijn R. Tannemaat, Jan J.G.M. Verschuuren, Gregor Kuhlenbäumer, Peter K. Gregersen, Maartje G. Huijbers, Frauke Stascheit, Andreas Meisel and Stephan Ripke ()
Additional contact information
Alice Braun: Berlin
Sudhanshu Shekhar: University of North Carolina at Chapel Hill
Daniel F. Levey: Yale School of Medicine
Peter Straub: Vanderbilt University Medical Center
Julia Kraft: Berlin
Georgia M. Panagiotaropoulou: Berlin
Karl Heilbron: Berlin
Swapnil Awasthi: Berlin
Rafael Meleka Hanna: Berlin
Sarah Hoffmann: Berlin
Maike Stein: Berlin
Sophie Lehnerer: Berlin
Philipp Mergenthaler: Berlin
Abdelrahman G. Elnahas: University of Tartu
Apostolia Topaloudi: West Lafayette
Maria Koromina: New York
Teemu Palviainen: University of Helsinki
Bergrun Asbjornsdottir: Inc.
Hreinn Stefansson: Inc.
Astros Th. Skuladóttir: Inc.
Ingileif Jónsdóttir: Inc.
Kari Stefansson: Inc.
Kadri Reis: University of Tartu
Tõnu Esko: University of Tartu
Aarno Palotie: University of Helsinki
Frank Leypoldt: Kiel
Murray B. Stein: La Jolla
Pierre Fontanillas: Sunnyvale
Jaakko Kaprio: University of Helsinki
Joel Gelernter: Yale School of Medicine
Lea K. Davis: Vanderbilt University Medical Center
Peristera Paschou: West Lafayette
Martijn R. Tannemaat: Department of Neurology
Jan J.G.M. Verschuuren: Department of Neurology
Gregor Kuhlenbäumer: Kiel
Peter K. Gregersen: Manhasset
Maartje G. Huijbers: Department of Neurology
Frauke Stascheit: Berlin
Andreas Meisel: Berlin
Stephan Ripke: Berlin

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Myasthenia gravis (MG) is a rare autoantibody-mediated disease affecting the neuromuscular junction. We performed a genome-wide association study of 5708 MG cases and 432,028 controls of European ancestry and a replication study in 3989 cases and 226,643 controls provided by 23andMe Inc. We identified 12 independent genome-wide significant hits (P

Date: 2024
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DOI: 10.1038/s41467-024-53595-6

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