Visible-light-mediated deoxygenative transformation of 1,2-dicarbonyl compounds through energy transfer process

Yun-Xuan Luo, Jie Huang, Guojiao Wu, Xiang-Ying Tang () and Jin-Ping Qu
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Yun-Xuan Luo: Huazhong University of Science and Technology (HUST)
Jie Huang: Huazhong University of Science and Technology (HUST)
Guojiao Wu: Huazhong University of Science and Technology (HUST)
Xiang-Ying Tang: Huazhong University of Science and Technology (HUST)
Jin-Ping Qu: Huazhong University of Science and Technology (HUST)

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Through the energy transfer process, mild transformations can be achieved that are often difficult to realize under thermodynamic conditions. Herein, a visible-light-driven deoxygenative coupling of 1,2-dicarbonyl compounds for C–O, C–S, and C–N bonds construction is developed via triplet state 1,2-dicarbonyls, affording a wide range of α-functionalized ketones/esters under transition-metal and external photocatalyst free conditions. The usefulness of this method is demonstrated by gram-scale synthesis, late-stage functionalization of various carboxylic acid drugs, and the synthesis of natural products and drug molecules.

Date: 2024
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DOI: 10.1038/s41467-024-53635-1

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