Automated detection and de novo structure modeling of nucleic acids from cryo-EM maps

Tao Li, Hong Cao, Jiahua He and Sheng-You Huang ()
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Tao Li: Huazhong University of Science and Technology
Hong Cao: Huazhong University of Science and Technology
Jiahua He: Huazhong University of Science and Technology
Sheng-You Huang: Huazhong University of Science and Technology

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Cryo-electron microscopy (cryo-EM) is one of the most powerful experimental methods for macromolecular structure determination. However, accurate DNA/RNA structure modeling from cryo-EM maps is still challenging especially for protein-DNA/RNA or multi-chain DNA/RNA complexes. Here we propose a deep learning-based method for accurate de novo structure determination of DNA/RNA from cryo-EM maps at

Date: 2024
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DOI: 10.1038/s41467-024-53721-4

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