Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023

Paola Cristina Resende (), Dennis M. Junqueira, Caroline Tochetto, Maria Ogrzewalska, Fernando C. Motta, Jonathan Lopes, Luciana Appolinario, Larissa Macedo, Braulia Caetano, Aline Matos, Thauane Silva, Elisa Cavalcante Pereira, Leticia Ferreira Lima, Irina Riediger, Maria do Carmo Debur, Guilherme Nardi Becker, Aline Andrade, Acácia Maria Lourenço Francisco Nasr, Rosana Aparecida Piler, Ana Carolina Dalla Vecchia, Walquíria Almeida, David Brown, Rejane Schaefer and Marilda M. Siqueira
Additional contact information
Paola Cristina Resende: Oswaldo Cruz Foundation
Dennis M. Junqueira: Universidade Federal de Santa Maria (UFSM)
Caroline Tochetto: Embrapa Suínos e Aves
Maria Ogrzewalska: Oswaldo Cruz Foundation
Fernando C. Motta: Oswaldo Cruz Foundation
Jonathan Lopes: Oswaldo Cruz Foundation
Luciana Appolinario: Oswaldo Cruz Foundation
Larissa Macedo: Oswaldo Cruz Foundation
Braulia Caetano: Oswaldo Cruz Foundation
Aline Matos: Oswaldo Cruz Foundation
Thauane Silva: Oswaldo Cruz Foundation
Elisa Cavalcante Pereira: Oswaldo Cruz Foundation
Leticia Ferreira Lima: Oswaldo Cruz Foundation
Irina Riediger: Laboratório Central do Estado do Paraná (LACEN-PR)
Maria do Carmo Debur: Laboratório Central do Estado do Paraná (LACEN-PR)
Guilherme Nardi Becker: Laboratório Central do Estado do Paraná (LACEN-PR)
Aline Andrade: Laboratório Central do Estado do Paraná (LACEN-PR)
Acácia Maria Lourenço Francisco Nasr: (SESA/PR)
Rosana Aparecida Piler: (SESA/PR)
Ana Carolina Dalla Vecchia: (SESA/PR)
Walquíria Almeida: Ministério da Saúde
David Brown: Oswaldo Cruz Foundation
Rejane Schaefer: Embrapa Suínos e Aves
Marilda M. Siqueira: Oswaldo Cruz Foundation

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020–2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.3.3.2/pdm09, 1B/human-like, and H3.1990.5), including three H1N1v, two H1N2v, two H3N2v and one H1v. Five H1v were closely related to pdm09 lineage, one H1v (H1N2v) grouped within 1B.2.3 clade, and the two H3v grouped within a clade composed exclusively of Brazilian H3 swIAV (clade H3.1990.5.1). Internal gene segments were closely related to H1N1pdm09 isolated from pigs. IAV variant rarely result in sustained transmission between people, however the potential to develop such ability is of concern and must not be underestimated. This study brings into focus the need for continuous influenza surveillance and timely risk assessment.

Date: 2024
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DOI: 10.1038/s41467-024-53815-z

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