Distinct Escherichia coli transcriptional profiles in the guts of recurrent UTI sufferers revealed by pangenome hybrid selection

Mark G. Young, Timothy J. Straub, Colin J. Worby, Hayden C. Metsky, Andreas Gnirke, Ryan A. Bronson, Lucas R. van Dijk, Christopher A. Desjardins, Christian Matranga, James Qu, Jesús Bazan Villicana, Philippe Azimzadeh, Andrew Kau, Karen W. Dodson, Henry L. Schreiber, Abigail L. Manson, Scott J. Hultgren and Ashlee M. Earl ()
Additional contact information
Mark G. Young: Broad Institute
Timothy J. Straub: Broad Institute
Colin J. Worby: Broad Institute
Hayden C. Metsky: Broad Institute
Andreas Gnirke: Broad Institute
Ryan A. Bronson: Broad Institute
Lucas R. van Dijk: Broad Institute
Christopher A. Desjardins: Broad Institute
Christian Matranga: Broad Institute
James Qu: Broad Institute
Jesús Bazan Villicana: Washington University School of Medicine
Philippe Azimzadeh: Washington University School of Medicine
Andrew Kau: Washington University School of Medicine
Karen W. Dodson: Washington University School of Medicine
Henry L. Schreiber: Washington University School of Medicine
Abigail L. Manson: Broad Institute
Scott J. Hultgren: Washington University School of Medicine
Ashlee M. Earl: Broad Institute

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Low-abundance members of microbial communities are difficult to study in their native habitats, including Escherichia coli, a minor but common inhabitant of the gastrointestinal tract, and key opportunistic pathogen of the urinary tract. While multi-omic analyses have detailed interactions between uropathogenic Escherichia coli (UPEC) and the bladder mediating urinary tract infection (UTI), little is known about UPEC in its pre-infection reservoir, the gastrointestinal tract, partly due to its low relative abundance (

Date: 2024
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DOI: 10.1038/s41467-024-53829-7

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