A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights

Jing Yu, Xiuqi Gui, Yunhao Zou, Qian Liu, Zhicheng Yang, Jusheng An, Xuan Guo, Kaihua Wang, Jiaming Guo, Manni Huang, Shuhan Zhou, Jing Zuo, Yimin Chen, Lu Deng, Guangwen Yuan, Ning Li, Yan Song, Jia Jia, Jia Zeng, Yuxi Zhao, Xianming Liu, Xiaoxian Du, Yansheng Liu, Pei Wang, Bing Zhang, Li Ding, Ana I. Robles, Henry Rodriguez, Hu Zhou (), Zhen Shao (), Lingying Wu () and Daming Gao ()
Additional contact information
Jing Yu: Chinese Academy of Medical Sciences and Peking Union Medical College
Xiuqi Gui: Chinese Academy of Sciences
Yunhao Zou: Chinese Academy of Sciences
Qian Liu: Chinese Academy of Sciences
Zhicheng Yang: University of Chinese Academy of Sciences
Jusheng An: Chinese Academy of Medical Sciences and Peking Union Medical College
Xuan Guo: Chinese Academy of Sciences
Kaihua Wang: Chinese Academy of Sciences
Jiaming Guo: University of Chinese Academy of Sciences
Manni Huang: Chinese Academy of Medical Sciences and Peking Union Medical College
Shuhan Zhou: Chinese Academy of Sciences
Jing Zuo: Chinese Academy of Medical Sciences and Peking Union Medical College
Yimin Chen: University of Chinese Academy of Sciences
Lu Deng: Chinese Academy of Medical Sciences and Peking Union Medical College
Guangwen Yuan: Chinese Academy of Medical Sciences and Peking Union Medical College
Ning Li: Chinese Academy of Medical Sciences and Peking Union Medical College
Yan Song: Chinese Academy of Medical Sciences and Peking Union Medical College
Jia Jia: Chinese Academy of Medical Sciences and Peking Union Medical College
Jia Zeng: Chinese Academy of Medical Sciences and Peking Union Medical College
Yuxi Zhao: Chinese Academy of Medical Sciences and Peking Union Medical College
Xianming Liu: Ltd
Xiaoxian Du: Ltd
Yansheng Liu: Yale University School of Medicine
Pei Wang: Icahn School of Medicine at Mount Sinai
Bing Zhang: One Baylor Plaza
Li Ding: Washington University
Ana I. Robles: National Institutes of Health
Henry Rodriguez: National Institutes of Health
Hu Zhou: University of Chinese Academy of Sciences
Zhen Shao: Chinese Academy of Sciences
Lingying Wu: Chinese Academy of Medical Sciences and Peking Union Medical College
Daming Gao: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-23

Abstract: Abstract Although the incidence of cervical cancer (CC) has been reduced in high-income countries due to human papillomavirus (HPV) vaccination and screening strategies, it remains a significant public health issue that poses a threat to women’s health in low-income countries. Here, we perform a comprehensive proteogenomic profiling of CC tumors obtained from 139 Chinese women. Integrated proteogenomic analysis links genetic aberrations to downstream pathogenesis-related pathways and reveals the landscape of HPV-associated multi-omic changes. EP300 is found to enhance the acetylation of FOSL2-K222, consequently accelerating the malignant proliferation of CC cells. Proteomic stratification identifies three patient subgroups with distinct features in prognosis, genetic alterations, immune infiltration, and post-translational modification regulations. PRKCB is further identified as a potential radioresponse-related biomarker of CC patients. This study provides a valuable public resource for researchers and clinicians to delve into the molecular basis of CC, to identify potential treatments and to ultimately advance clinical practice.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-53830-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-53830-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-53830-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().