An ultrasensitive multimodal intracranial pressure biotelemetric system enabled by exceptional point and iontronics

Jie Li, Fan Zhang, Xiaobin Xia, Kaihang Zhang, Jianhui Wu, Yulu Liu, Chi Zhang, Xinyu Cai, Jiaqi Lu, Liangquan Xu, Rui Wan, Dinku Hazarika, Weipeng Xuan (), Jinkai Chen, Zhen Cao, Yubo Li, Hao Jin, Shurong Dong, Shaomin Zhang (), Zhilu Ye, Minye Yang (), Pai-Yen Chen and Jikui Luo ()
Additional contact information
Jie Li: Zhejiang University
Fan Zhang: Zhejiang University
Xiaobin Xia: Hangzhou Dianzi University
Kaihang Zhang: Zhejiang University
Jianhui Wu: Zhejiang University
Yulu Liu: Zhejiang University
Chi Zhang: Zhejiang University
Xinyu Cai: Zhejiang University
Jiaqi Lu: Zhejiang University
Liangquan Xu: Zhejiang University
Rui Wan: Zhejiang University
Dinku Hazarika: Zhejiang University
Weipeng Xuan: Hangzhou Dianzi University
Jinkai Chen: Hangzhou Dianzi University
Zhen Cao: Zhejiang University
Yubo Li: Zhejiang University
Hao Jin: Zhejiang University
Shurong Dong: Zhejiang University
Shaomin Zhang: Zhejiang University
Zhilu Ye: Xi’an Jiaotong University
Minye Yang: Xi’an Jiaotong University
Pai-Yen Chen: University of Illinois Chicago
Jikui Luo: Zhejiang University

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract The accurate monitoring of vital physiological parameters, exemplified by heart rate, respiratory rate, and intracranial pressure (ICP), is of paramount importance, particularly for managing severe cranial injuries. Despite the rapid development of implantable ICP sensing systems over the past decades, they still suffer from, for example, wire connection, low sensitivity, poor resolution, and the inability to monitor multiple variables simultaneously. Here, we propose an ultrasensitive multimodal biotelemetric system that amalgamates an iontronic pressure transducer with exceptional point (EP) operation for the monitoring of ICP signals. The proposed system can exhibit extraordinary performance regarding the detection of minuscule ICP fluctuation, demonstrated by the sensitivity of 115.95 kHz/mmHg and the sensing resolution down to 0.003 mmHg. Our system excels not only in the accurate quantification of ICP levels but also in distinguishing respiration and cardiac activities from ICP signals, thereby achieving the multimodal monitoring of ICP, respiratory, and heart rates within a single system. Our work may provide a pragmatic avenue for the real-time wireless monitoring of ICP and thus hold great potential to be extended to the monitoring of other vital physiological indicators.

Date: 2024
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DOI: 10.1038/s41467-024-53836-8

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