Constructing organoid-brain-computer interfaces for neurofunctional repair after brain injury

Nan Hu, Jian-Xin Shi, Chong Chen, Hai-Huan Xu, Zhe-Han Chang, Peng-Fei Hu, Di Guo, Xiao-Wang Zhang, Wen-Wei Shao, Xiu Fan, Jia-Chen Zuo, Dong Ming and Xiao-Hong Li ()
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Nan Hu: Tianjin University
Jian-Xin Shi: Tianjin University
Chong Chen: Tianjin University
Hai-Huan Xu: Tianjin University
Zhe-Han Chang: Tianjin University
Peng-Fei Hu: Tianjin University
Di Guo: Tianjin University
Xiao-Wang Zhang: Tianjin University
Wen-Wei Shao: Tianjin University
Xiu Fan: Tianjin University
Jia-Chen Zuo: Tianjin University
Dong Ming: Tianjin University
Xiao-Hong Li: Tianjin University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract The reconstruction of damaged neural circuits is critical for neurological repair after brain injury. Classical brain-computer interfaces (BCIs) allow direct communication between the brain and external controllers to compensate for lost functions. Importantly, there is increasing potential for generalized BCIs to input information into the brains to restore damage, but their effectiveness is limited when a large injured cavity is caused. Notably, it might be overcome by transplantation of brain organoids into the damaged region. Here, we construct innovative BCIs mediated by implantable organoids, coined as organoid-brain-computer interfaces (OBCIs). We assess the prolonged safety and feasibility of the OBCIs, and explore neuroregulatory strategies. OBCI stimulation promotes progressive differentiation of grafts and enhances structural-functional connections within organoids and the host brain, promising to repair the damaged brain via regenerating and regulating, potentially directing neurons to preselected targets and recovering functional neural networks in the future.

Date: 2024
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DOI: 10.1038/s41467-024-53858-2

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