The Arabidopsis receptor-like kinase WAKL4 limits cadmium uptake via phosphorylation and degradation of NRAMP1 transporter

Jun Jie Yuan, Ya Nan Zhao, Su Hang Yu, Ying Sun, Gui Xin Li, Jing Ying Yan, Ji Ming Xu, Wo Na Ding, Moussa Benhamed, Rong Liang Qiu, Chong Wei Jin, Shao Jian Zheng and Zhong Jie Ding ()
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Jun Jie Yuan: Zhejiang University
Ya Nan Zhao: Zhejiang University
Su Hang Yu: Zhejiang University
Ying Sun: Ningxia University
Gui Xin Li: Zhejiang University
Jing Ying Yan: Zhejiang University
Ji Ming Xu: Zhejiang University
Wo Na Ding: Ningbo University
Moussa Benhamed: Institute of Plant Sciences Paris-Saclay (IPS2)
Rong Liang Qiu: South China Agricultural University
Chong Wei Jin: Zhejiang University
Shao Jian Zheng: Zhejiang University
Zhong Jie Ding: Zhejiang University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Cadmium (Cd) is a detrimental heavy metal propagated from soil to the food chain via plants, posing a great risk to human health upon consumption. Despite the understanding of Cd tolerance mechanisms in plants, whether and how plants actively respond to Cd and in turn restrict its uptake and accumulation remain elusive. Here, we identify a cell wall-associated receptor-like kinase 4 (WAKL4) involved in specific tolerance to Cd stress. We show that Cd rapidly and exclusively induces WAKL4 accumulation by promoting WAKL4 transcription and blocking its vacuole-dependent proteolysis in roots. The accumulated WAKL4 next interacts with and phosphorylates the Cd transporter NRAMP1 at Tyr488, leading to the enhanced ubiquitination and vacuole-dependent degradation of NRAMP1, and consequently reducing Cd uptake. Our findings therefore uncover a mechanism conferred by the WAKL4-NRAMP1 module that enables plants to actively respond to Cd and limit its uptake, informing the future molecular breeding of low Cd accumulated crops or vegetables.

Date: 2024
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DOI: 10.1038/s41467-024-53898-8

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