Next-generation rapid phenotypic antimicrobial susceptibility testing

Grace Reszetnik, Keely Hammond, Sara Mahshid, Tamer AbdElFatah, Dao Nguyen, Rachel Corsini, Chelsea Caya, Jesse Papenburg, Matthew P. Cheng and Cedric P. Yansouni ()
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Grace Reszetnik: McGill University
Keely Hammond: McGill University Health Centre
Sara Mahshid: McGill University
Tamer AbdElFatah: McGill University
Dao Nguyen: McGill University
Rachel Corsini: Institute of the McGill University Health Centre
Chelsea Caya: Institute of the McGill University Health Centre
Jesse Papenburg: Institute of the McGill University Health Centre
Matthew P. Cheng: McGill University Health Centre
Cedric P. Yansouni: McGill University Health Centre

Nature Communications, 2024, vol. 15, issue 1, 1-21

Abstract: Abstract Slow progress towards implementation of conventional clinical bacteriology in low resource settings and strong interest in greater speed for antimicrobial susceptibility testing (AST) more generally has focused attention on next-generation rapid AST technologies. In this Review, we systematically synthesize publications and submissions to regulatory agencies describing technologies that provide phenotypic AST faster than conventional methods. We characterize over ninety technologies in terms of underlying technical innovations, technology readiness level, extent of clinical validation, and time-to-results. This work provides a guide for technology developers and clinical microbiologists to understand the rapid phenotypic AST technology landscape, current development pipeline, and AST-specific validation milestones.

Date: 2024
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DOI: 10.1038/s41467-024-53930-x

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