Large-scale metagenomic analysis of oral microbiomes reveals markers for autism spectrum disorders

Paolo Manghi (), Michele Filosi, Moreno Zolfo, Lucas G. Casten, Albert Garcia-Valiente, Stefania Mattevi, Vitor Heidrich, Davide Golzato, Samuel Perini, Andrew M. Thomas, Simone Montalbano, Samuele Cancellieri, Levi Waldron, Jacob B. Hall, Simon Xu, Natalia Volfovsky, LeeAnne Green Snyder, Pamela Feliciano, Francesco Asnicar, Mireia Valles-Colomer, Jacob J. Michaelson, Nicola Segata () and Enrico Domenici ()
Additional contact information
Paolo Manghi: University of Trento
Michele Filosi: University of Trento
Moreno Zolfo: University of Trento
Lucas G. Casten: University of Iowa
Albert Garcia-Valiente: University of Trento
Stefania Mattevi: University of Trento
Vitor Heidrich: University of Trento
Davide Golzato: University of Trento
Samuel Perini: University of Trento
Andrew M. Thomas: University of Trento
Simone Montalbano: University of Trento
Samuele Cancellieri: University of Trento
Levi Waldron: Institute for Implementation Science in Public Health
Jacob B. Hall: Simons Foundation
Simon Xu: Simons Foundation
Natalia Volfovsky: Simons Foundation
LeeAnne Green Snyder: Simons Foundation
Pamela Feliciano: Simons Foundation
Francesco Asnicar: University of Trento
Mireia Valles-Colomer: University Pompeu Fabra
Jacob J. Michaelson: University of Iowa
Nicola Segata: University of Trento
Enrico Domenici: University of Trento

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract The link between the oral microbiome and neurodevelopmental disorders remains a compelling hypothesis, still requiring confirmation in large-scale datasets. Leveraging over 7000 whole-genome sequenced salivary samples from 2025 US families with children diagnosed with autism spectrum disorders (ASD), our cross-sectional study shows that the oral microbiome composition can discriminate ASD subjects from neurotypical siblings (NTs, AUC = 0.66), with 108 differentiating species (q

Date: 2024
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DOI: 10.1038/s41467-024-53934-7

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