Long-term machine perfusion of human split livers: a new model for regenerative and translational research

Ngee-Soon Lau, Geoffrey McCaughan, Mark Ly, Ken Liu, Michael Crawford and Carlo Pulitano ()
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Ngee-Soon Lau: Royal Prince Alfred Hospital
Geoffrey McCaughan: Royal Prince Alfred Hospital
Mark Ly: Royal Prince Alfred Hospital
Ken Liu: Royal Prince Alfred Hospital
Michael Crawford: Royal Prince Alfred Hospital
Carlo Pulitano: Royal Prince Alfred Hospital

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Recent advances in machine perfusion have revolutionised the field of transplantation by prolonging preservation, permitting evaluation of viability prior to implant and rescue of discarded organs. Long-term perfusion for days-to-weeks provides time to modify these organs prior to transplantation. By using long-term normothermic machine perfusion to facilitate liver splitting and subsequent perfusion of both partial organs, possibilities even outside the clinical arena become possible. This model remains in its infancy but in the future, could allow for detailed study of liver injury and regeneration, and ex-situ treatment strategies such as defatting, genetic modulation and stem-cell therapies. Here we provide insight into this new model for research and highlight its great potential and current limitations.

Date: 2024
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DOI: 10.1038/s41467-024-54024-4

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