A single NLR gene confers resistance to leaf and stripe rust in wheat

Davinder Sharma, Raz Avni, Juan Gutierrez-Gonzalez, Rakesh Kumar, Hanan Sela, Manas Ranjan Prusty, Arava Shatil-Cohen, István Molnár, Kateřina Holušová, Mahmoud Said, Jaroslav Doležel, Eitan Millet, Sofia Khazan-Kost, Udi Landau, Gerit Bethke, Or Sharon, Smadar Ezrati, Moshe Ronen, Oxana Maatuk, Tamar Eilam, Jacob Manisterski, Pnina Ben-Yehuda, Yehoshua Anikster, Oadi Matny, Brian J. Steffenson, Martin Mascher, Helen J. Brabham, Matthew J. Moscou, Yong Liang, Guotai Yu, Brande B. H. Wulff, Gary Muehlbauer (), Anna Minz-Dub () and Amir Sharon ()
Additional contact information
Davinder Sharma: Tel Aviv University
Raz Avni: Tel Aviv University
Juan Gutierrez-Gonzalez: University of Minnesota
Rakesh Kumar: Tel Aviv University
Hanan Sela: Tel Aviv University
Manas Ranjan Prusty: Tel Aviv University
Arava Shatil-Cohen: Tel Aviv University
István Molnár: Institute of Experimental Botany of the Czech Academy of Sciences, Centre of Plant Structural and Functional Genomics
Kateřina Holušová: Institute of Experimental Botany of the Czech Academy of Sciences, Centre of Plant Structural and Functional Genomics
Mahmoud Said: Institute of Experimental Botany of the Czech Academy of Sciences, Centre of Plant Structural and Functional Genomics
Jaroslav Doležel: Institute of Experimental Botany of the Czech Academy of Sciences, Centre of Plant Structural and Functional Genomics
Eitan Millet: Tel Aviv University
Sofia Khazan-Kost: Tel Aviv University
Udi Landau: Tel Aviv University
Gerit Bethke: University of Minnesota
Or Sharon: Tel Aviv University
Smadar Ezrati: Tel Aviv University
Moshe Ronen: Tel Aviv University
Oxana Maatuk: Tel Aviv University
Tamar Eilam: Tel Aviv University
Jacob Manisterski: Tel Aviv University
Pnina Ben-Yehuda: Tel Aviv University
Yehoshua Anikster: Tel Aviv University
Oadi Matny: University of Minnesota
Brian J. Steffenson: University of Minnesota
Martin Mascher: Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben
Helen J. Brabham: Norwich Research Park
Matthew J. Moscou: University of Minnesota
Yong Liang: Tel Aviv University
Guotai Yu: Norwich Research Park
Brande B. H. Wulff: Norwich Research Park
Gary Muehlbauer: University of Minnesota
Anna Minz-Dub: Tel Aviv University
Amir Sharon: Tel Aviv University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Nucleotide-binding leucine-rich repeat (NLR) disease resistance genes typically confer resistance against races of a single pathogen. Here, we report that Yr87/Lr85, an NLR gene from Aegilops sharonensis and Aegilops longissima, confers resistance against both P. striiformis tritici (Pst) and Puccinia triticina (Pt) that cause stripe and leaf rust, respectively. Yr87/Lr85 confers resistance against Pst and Pt in wheat introgression as well as transgenic lines. Comparative analysis of Yr87/Lr85 and the cloned Triticeae NLR disease resistance genes shows that Yr87/Lr85 contains two distinct LRR domains and that the gene is only found in Ae. sharonensis and Ae. longissima. Allele mining and phylogenetic analysis indicate multiple events of Yr87/Lr85 gene flow between the two species and presence/absence variation explaining the majority of resistance to wheat leaf rust in both species. The confinement of Yr87/Lr85 to Ae. sharonensis and Ae. longissima and the resistance in wheat against Pst and Pt highlight the potential of these species as valuable sources of disease resistance genes for wheat improvement.

Date: 2024
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DOI: 10.1038/s41467-024-54068-6

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