The outcomes of SGLT-2 inhibitor utilization in diabetic kidney transplant recipients

Jia-Yuh Sheu, Li-Yang Chang, Jui-Yi Chen, Heng-Chih Pan, Chi-Shin Tseng, Jeff S. Chueh () and Vin-Cent Wu ()
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Jia-Yuh Sheu: National Taiwan University Hospital
Li-Yang Chang: National Taiwan University
Jui-Yi Chen: Chi-Mei Medical Center
Heng-Chih Pan: National Taiwan University
Chi-Shin Tseng: National Taiwan University Hospital
Jeff S. Chueh: National Taiwan University Hospital
Vin-Cent Wu: National Taiwan University Hospital

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) have demonstrated efficacy in reducing cardiovascular events and potentially improving kidney function in diabetic patients. This investigation analyzes the TriNetX database to assess the efficacy of SGLT-2i in diabetic kidney transplant recipients (KTR) concerning all-cause mortality, major adverse cardiac events (MACE), and major adverse kidney events (MAKE). The study includes type 2 diabetic patients over 18 who underwent kidney transplants between June 1, 2015, and June 1, 2023, with a focus on SGLT-2i use within the first three months post-transplant. After propensity score matching, the study compares 1970 SGLT-2i users with matched non-users. With a median follow-up of 3.4 years, SGLT-2i users showed significantly lower rates of all-cause mortality (adjusted hazard ratio [aHR]: 0.32), MACE (aHR: 0.48), and MAKE (aHR: 0.52). These findings indicate that SGLT-2i significantly reduces mortality and adverse events in diabetic KTR, underscoring its potential to improve post-transplant outcomes.

Date: 2024
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DOI: 10.1038/s41467-024-54171-8

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