Ordered assemblies of peptide nanoparticles with only positive charge

Yi Shi, Tianren Zhang, Rui Guo, Zihan Zhang, Amanda L. McCahill, Yao Tang, Sabrina E. Liskey, Dai-Bei Yang, Christopher J. Kloxin, Jeffery G. Saven () and Darrin J. Pochan ()
Additional contact information
Yi Shi: University of Delaware
Tianren Zhang: University of Delaware
Rui Guo: University of Pennsylvania
Zihan Zhang: University of Delaware
Amanda L. McCahill: University of Delaware
Yao Tang: University of Delaware
Sabrina E. Liskey: University of Delaware
Dai-Bei Yang: University of Pennsylvania
Christopher J. Kloxin: University of Delaware
Jeffery G. Saven: University of Pennsylvania
Darrin J. Pochan: University of Delaware

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Surface charge patchiness of different charge types can influence the solution behaviours of colloidal particles and globular proteins. Herein, coiled-coil ‘bundlemer’ nanoparticles that display only a single type of surface charge (SC) are computationally designed to compare their solution behaviours to mixed charge-type (MC) counterparts with both positively and negatively charged side chains. Nematic and columnar liquid crystal phases are discovered in low concentrations of SC particles, indicative of particle end-to-end stacking into columns combined with lateral electrostatic repulsion between columns, while MC particles with the same net charge and particle shape produced only amorphous, soluble aggregates. Similarly, porous lattices are formed in mixtures of SC/MC particles of opposite charges while MC/MC mixtures of opposite charges produce only amorphous aggregates. The lattice structure is inferred with a machine learning optimization approach. The differences between SC and MC particle behaviours directly show the importance of surface electrostatic patchiness.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-54340-9 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54340-9

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-54340-9

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().