Histamine-tuned subicular circuit mediates alert-driven accelerated locomotion in mice

Lin Yang, Mengdi Zhang, Yuan Zhou, Dongxiao Jiang, Lilong Yu, Lingyu Xu, Fan Fei, Wenkai Lin, Yanrong Zheng, Jiannong Wu, Yi Wang () and Zhong Chen ()
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Lin Yang: Zhejiang Chinese Medical University
Mengdi Zhang: Zhejiang Chinese Medical University
Yuan Zhou: Zhejiang Chinese Medical University
Dongxiao Jiang: Zhejiang Chinese Medical University
Lilong Yu: Zhejiang Chinese Medical University
Lingyu Xu: Zhejiang Chinese Medical University
Fan Fei: Zhejiang Chinese Medical University
Wenkai Lin: Zhejiang Chinese Medical University
Yanrong Zheng: Zhejiang Chinese Medical University
Jiannong Wu: Zhejiang Chinese Medical University
Yi Wang: Zhejiang Chinese Medical University
Zhong Chen: Zhejiang Chinese Medical University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract The locomotive action involves diverse coordination, necessitating the integration of multiple motor neural circuits. However, the precise circuitry mechanism governing emotion-driven accelerated locomotion remains predominantly elusive. Here we dissect projections from the tuberomammillary nucleus (TMN) to subiculum (SUB) which promote alert-driven accelerated locomotion. We find that TMN histaminergic neurons respond to high-speed locomotion in both natural and alert acceleration. The TMN-SUB circuit is sufficient but not essential for amplifying accelerated locomotion from low to high-speed movement in basal condition, but it is both sufficient and necessary in alert condition for modulating accelerated locomotion during high-speed escape behavior. TMN histaminergic neuron activates SUB glutamatergic “fast locomotor cell” that projects to retrosplenial granular cortex (RSG) mainly through histamine H2 receptor (H2R). This study reveals the critical role of the histamine-tuned SUB circuit in alert-driven accelerated locomotion in mice, providing a theoretical foundation for comprehending neural circuit mechanisms of instinctive behaviors under alert.

Date: 2024
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DOI: 10.1038/s41467-024-54347-2

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