Genomic perspective on the bacillus causing paratyphoid B fever

Jane Hawkey, Lise Frézal, Alicia Tran Dien, Anna Zhukova, Derek Brown, Marie Anne Chattaway, Sandra Simon, Hidemasa Izumiya, Patricia I. Fields, Niall De Lappe, Lidia Kaftyreva, Xuebin Xu, Junko Isobe, Dominique Clermont, Elisabeth Njamkepo, Yukihiro Akeda, Sylvie Issenhuth-Jeanjean, Mariia Makarova, Yanan Wang, Martin Hunt, Brent M. Jenkins, Magali Ravel, Véronique Guibert, Estelle Serre, Zoya Matveeva, Laëtitia Fabre, Martin Cormican, Min Yue, Baoli Zhu, Masatomo Morita, Zamin Iqbal, Carolina Silva Nodari, Maria Pardos de la Gandara and François-Xavier Weill ()
Additional contact information
Jane Hawkey: Monash University
Lise Frézal: Université Paris Cité, Unité des Bactéries pathogènes entériques
Alicia Tran Dien: Université Paris Cité, Unité des Bactéries pathogènes entériques
Anna Zhukova: Université Paris Cité, Bioinformatics and Biostatistics Hub
Derek Brown: Scottish Microbiology Reference Laboratories (SMiRL)
Marie Anne Chattaway: United Kingdom Health Security Agency
Sandra Simon: Robert Koch-Institute
Hidemasa Izumiya: National Institute of Infectious Diseases
Patricia I. Fields: Centers for Disease Control and Prevention
Niall De Lappe: Galway University Hospitals
Lidia Kaftyreva: Pasteur Institute of St Petersburg
Xuebin Xu: Shanghai Municipal Centre for Disease Control and Prevention
Junko Isobe: Toyama Institute of Health
Dominique Clermont: Université Paris Cité, Collection of Institut Pasteur (CIP)
Elisabeth Njamkepo: Université Paris Cité, Unité des Bactéries pathogènes entériques
Yukihiro Akeda: National Institute of Infectious Diseases
Sylvie Issenhuth-Jeanjean: Université Paris Cité, Unité des Bactéries pathogènes entériques
Mariia Makarova: Pasteur Institute of St Petersburg
Yanan Wang: Henan Agricultural University
Martin Hunt: European Bioinformatics Institute
Brent M. Jenkins: Centers for Disease Control and Prevention
Magali Ravel: Université Paris Cité, Unité des Bactéries pathogènes entériques
Véronique Guibert: Université Paris Cité, Unité des Bactéries pathogènes entériques
Estelle Serre: Université Paris Cité, Unité des Bactéries pathogènes entériques
Zoya Matveeva: Pasteur Institute of St Petersburg
Laëtitia Fabre: Université Paris Cité, Unité des Bactéries pathogènes entériques
Martin Cormican: Galway University Hospitals
Min Yue: Zhejiang University College of Animal Sciences
Baoli Zhu: Chinese Academy of Sciences (CAS)
Masatomo Morita: National Institute of Infectious Diseases
Zamin Iqbal: European Bioinformatics Institute
Carolina Silva Nodari: Université Paris Cité, Unité des Bactéries pathogènes entériques
Maria Pardos de la Gandara: Université Paris Cité, Unité des Bactéries pathogènes entériques
François-Xavier Weill: Université Paris Cité, Unité des Bactéries pathogènes entériques

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.

Date: 2024
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DOI: 10.1038/s41467-024-54418-4

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