Super-resolved coherent anti-Stokes Raman scattering microscopy by coherent image scanning

Anna Zhitnitsky, Elad Benjamin, Ora Bitton and Dan Oron ()
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Anna Zhitnitsky: Weizmann Institute of Science
Elad Benjamin: Weizmann Institute of Science
Ora Bitton: Weizmann Institute of Science
Dan Oron: Weizmann Institute of Science

Nature Communications, 2024, vol. 15, issue 1, 1-7

Abstract: Abstract We present super-resolved coherent anti-Stokes Raman scattering (CARS) microscopy by implementing phase-resolved image scanning microscopy, achieving up to two-fold resolution increase as compared with a conventional CARS microscope. Phase-sensitivity is required for the standard pixel-reassignment procedure since the scattered field is coherent, thus the point-spread function is well-defined only for the field amplitude. We resolve the complex field by a simple add-on to the CARS setup enabling inline interferometry. Phase-sensitivity offers additional contrast which informs the spatial distribution of both resonant and nonresonant scatterers. As compared with alternative super-resolution schemes in coherent nonlinear microscopy, the proposed method is simple, requires only low-intensity excitation, and is compatible with any conventional forward-detected CARS imaging setup.

Date: 2024
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DOI: 10.1038/s41467-024-54429-1

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