Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years

Michelle A. Neller, George R. Ambalathingal, Nada Hamad, Joe Sasadeusz, Rebecca Pearson, Chien-Li Holmes-Liew, Deepak Singhal, Matthew Tunbridge, Wei Yang Ng, Kirsty Sharplin, Andrew Moore, David Deambrosis, Trisha Soosay-Raj, Peter McNaughton, Morag Whyte, Chris Fraser, Andrew Grigg, David Kliman, Ashish Bajel, Katherine Cummins, Mark Dowling, Zhi Han Yeoh, Simon J. Harrison, Amit Khot, Sarah Tan, Izanne Roos, Ray Mun Koo, Sara Dohrmann, David Ritchie, Brynn Wainstein, Karen McCleary, Adam Nelson, Bradley Gardiner, Shafqat Inam, Xavier Badoux, Kris Ma, Claudia Toro, Diane Hanna, David Hughes, Rachel Conyers, Theresa Cole, Shiqi Stacie Wang, Lynette Chee, Jacqueline Fleming, Ashley Irish, Duncan Purtill, Julian Cooney, Peter Shaw, Siok-Keen Tey, Stewart Hunt, Elango Subramonia Pillai, George John, Michelle Ng, Shanti Ramachandran, Peter Hopkins, Daniel Chambers, Scott Campbell, Ross Francis, Nicole Isbel, Paula Marlton, Hilary Reddiex, Katherine K. Matthews, Meggie Voogt, Archana Panikkar, Leone Beagley, Sweera Rehan, Shannon Best, Jyothy Raju, Laetitia Texier, Pauline Crooks, Matthew Solomon, Lea Lekieffre, Sriganesh Srihari, Corey Smith and Rajiv Khanna ()
Additional contact information
Michelle A. Neller: QIMR Berghofer Medical Research Institute
George R. Ambalathingal: QIMR Berghofer Medical Research Institute
Nada Hamad: University of Notre Dame
Joe Sasadeusz: University of Notre Dame
Rebecca Pearson: University of Notre Dame
Chien-Li Holmes-Liew: Royal Adelaide Hospital
Deepak Singhal: Royal Adelaide Hospital
Matthew Tunbridge: Royal Adelaide Hospital
Wei Yang Ng: Royal Adelaide Hospital
Kirsty Sharplin: Royal Adelaide Hospital
Andrew Moore: Queensland Children’s Hospital
David Deambrosis: Queensland Children’s Hospital
Trisha Soosay-Raj: Queensland Children’s Hospital
Peter McNaughton: Queensland Children’s Hospital
Morag Whyte: Queensland Children’s Hospital
Chris Fraser: Queensland Children’s Hospital
Andrew Grigg: Heidelberg
David Kliman: St Leonards
Ashish Bajel: University of Melbourne
Katherine Cummins: University of Melbourne
Mark Dowling: University of Melbourne
Zhi Han Yeoh: University of Melbourne
Simon J. Harrison: University of Melbourne
Amit Khot: University of Melbourne
Sarah Tan: University of Melbourne
Izanne Roos: University of Melbourne
Ray Mun Koo: University of Melbourne
Sara Dohrmann: University of Melbourne
David Ritchie: University of Melbourne
Brynn Wainstein: Sydney Children’s Hospital
Karen McCleary: Sydney Children’s Hospital
Adam Nelson: Sydney Children’s Hospital
Bradley Gardiner: Melbourne
Shafqat Inam: Melbourne
Xavier Badoux: St George Public Hospital
Kris Ma: Westmead Hospital
Claudia Toro: Royal Children’s Hospital Melbourne
Diane Hanna: Royal Children’s Hospital Melbourne
Rachel Conyers: Royal Children’s Hospital Melbourne
Theresa Cole: Royal Children’s Hospital Melbourne
Shiqi Stacie Wang: Royal Children’s Hospital Melbourne
Lynette Chee: Royal Children’s Hospital Melbourne
Jacqueline Fleming: Royal Children’s Hospital Melbourne
Ashley Irish: Fiona Stanley Hospital
Duncan Purtill: Fiona Stanley Hospital
Julian Cooney: Fiona Stanley Hospital
Peter Shaw: The Children’s Hospital at Westmead
Siok-Keen Tey: QIMR Berghofer Medical Research Institute
Stewart Hunt: Royal Brisbane and Women’s Hospital
Elango Subramonia Pillai: Royal Brisbane and Women’s Hospital
George John: Royal Brisbane and Women’s Hospital
Michelle Ng: Perth Children’s Hospital
Shanti Ramachandran: Perth Children’s Hospital
Peter Hopkins: The Prince Charles Hospital
Daniel Chambers: The Prince Charles Hospital
Scott Campbell: Princess Alexandra Hospital
Ross Francis: Princess Alexandra Hospital
Nicole Isbel: Princess Alexandra Hospital
Paula Marlton: Princess Alexandra Hospital
Hilary Reddiex: QIMR Berghofer Medical Research Institute
Katherine K. Matthews: QIMR Berghofer Medical Research Institute
Meggie Voogt: QIMR Berghofer Medical Research Institute
Archana Panikkar: QIMR Berghofer Medical Research Institute
Leone Beagley: QIMR Berghofer Medical Research Institute
Sweera Rehan: QIMR Berghofer Medical Research Institute
Shannon Best: QIMR Berghofer Medical Research Institute
Jyothy Raju: QIMR Berghofer Medical Research Institute
Laetitia Texier: QIMR Berghofer Medical Research Institute
Pauline Crooks: QIMR Berghofer Medical Research Institute
Matthew Solomon: QIMR Berghofer Medical Research Institute
Lea Lekieffre: QIMR Berghofer Medical Research Institute
Sriganesh Srihari: QIMR Berghofer Medical Research Institute
Corey Smith: QIMR Berghofer Medical Research Institute
Rajiv Khanna: QIMR Berghofer Medical Research Institute

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Adoptive T-cell immunotherapy holds great promise for the treatment of viral complications in immunocompromised patients resistant to standard anti-viral strategies. We present a retrospective analysis of 78 patients from 19 hospitals across Australia and New Zealand, treated over the last 15 years with “off-the-shelf” allogeneic T cells directed to a combination of Epstein–Barr virus (EBV), cytomegalovirus (CMV), BK polyomavirus (BKV), John Cunningham virus (JCV) and/or adenovirus (AdV) under the Australian Therapeutic Goods Administration’s Special Access Scheme. Most patients had severe post-transplant viral complications, including drug-resistant end-organ CMV disease, BKV-associated haemorrhagic cystitis and EBV-driven post-transplant lymphoproliferative disorder. Adoptive immunotherapy is well tolerated with few adverse effects. Importantly, 46/71 (65%) patients show definitive clinical improvement including reduction in viral load, clinical symptoms and complete resolution of end-organ disease. In addition, seven high-risk patients remain disease free. Based on this long-term encouraging clinical experience, we propose that a dedicated nationally funded centre for anti-viral cellular therapies should be considered to provide T cell therapies for critically ill patients for compassionate use.

Date: 2024
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DOI: 10.1038/s41467-024-54595-2

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