Population genomics of Plasmodium ovale species in sub-Saharan Africa

Kelly Carey-Ewend (), Zachary R. Popkin-Hall, Alfred Simkin, Meredith Muller, Chris Hennelly, Wenqiao He, Kara A. Moser, Claudia Gaither, Karamoko Niaré, Farhang Aghakanian, Sindew Feleke, Bokretsion G. Brhane, Fernandine Phanzu, Melchior Mwandagalirwa Kashamuka, Ozkan Aydemir, Colin J. Sutherland, Deus S. Ishengoma, Innocent M. Ali, Billy Ngasala, Albert Kalonji, Antoinette Tshefu, Jonathan B. Parr, Jeffrey A. Bailey, Jonathan J. Juliano and Jessica T. Lin
Additional contact information
Kelly Carey-Ewend: University of North Carolina
Zachary R. Popkin-Hall: University of North Carolina
Alfred Simkin: Brown University
Meredith Muller: University of North Carolina
Chris Hennelly: University of North Carolina
Wenqiao He: University of North Carolina
Kara A. Moser: University of North Carolina
Claudia Gaither: University of North Carolina
Karamoko Niaré: Brown University
Farhang Aghakanian: University of North Carolina
Sindew Feleke: Ethiopian Public Health Institute
Bokretsion G. Brhane: Ethiopian Public Health Institute
Fernandine Phanzu: SANRU Asbl
Melchior Mwandagalirwa Kashamuka: Kinshasa School of Public Health
Ozkan Aydemir: University of Massachusetts
Colin J. Sutherland: London School of Hygiene and Tropical Medicine
Deus S. Ishengoma: National Institute for Medical Research (NIMR)
Innocent M. Ali: University of Dschang
Billy Ngasala: Muhimbili University of Health and Allied Sciences
Albert Kalonji: SANRU Asbl
Antoinette Tshefu: Kinshasa School of Public Health
Jonathan B. Parr: University of North Carolina
Jeffrey A. Bailey: Brown University
Jonathan J. Juliano: University of North Carolina
Jessica T. Lin: University of North Carolina

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Plasmodium ovale curtisi (Poc) and Plasmodium ovale wallikeri (Pow) are relapsing malaria parasites endemic to Africa and Asia that were previously thought to represent a single species. Amid increasing detection of ovale malaria in sub-Saharan Africa, we present a population genomic study of both species across the continent. We conducted whole-genome sequencing of 25 isolates from Central and East Africa and analyzed them alongside 20 previously published African genomes. Isolates are predominantly monoclonal (43/45), with their genetic similarity aligning with geography. Pow shows lower average nucleotide diversity (1.8×10−4) across the genome compared to Poc (3.0×10−4) (p

Date: 2024
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DOI: 10.1038/s41467-024-54667-3

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