Maternal polycystic ovary syndrome and Offspring’s Risk of Cardiovascular diseases in Childhood and Young Adulthood

Fen Yang (), Ziliang Wang, Henrik Toft Sørensen, Imre Janszky, Mika Gissler, Wei Yuan, Maohua Miao, Nathalie Roos, Anna-Karin Wikström, Jiong Li and Krisztina D. László
Additional contact information
Fen Yang: Karolinska Institutet
Ziliang Wang: Shanghai Institute for Biomedical and Pharmaceutical Technologies
Henrik Toft Sørensen: Aarhus University and Aarhus University Hospital
Imre Janszky: Karolinska Institutet
Mika Gissler: Finnish Institute for Health and Welfare
Wei Yuan: Shanghai Institute for Biomedical and Pharmaceutical Technologies
Maohua Miao: Shanghai Institute for Biomedical and Pharmaceutical Technologies
Nathalie Roos: Karolinska University Hospital and Karolinska Institutet
Anna-Karin Wikström: Uppsala University
Jiong Li: Aarhus University Hospital
Krisztina D. László: Karolinska Institutet

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Children born to mothers with polycystic ovary syndrome have a higher prevalence of cardiovascular risk factors and of subclinical cardiovascular disease, but the association between maternal polycystic ovary syndrome and cardiovascular disease in offspring is unclear. We conduct a register-based cohort study of 6 839 703 live singleton births from Denmark (1973–2016) and Sweden (1973–2014) and follow them for up to 48 years. Using Cox regression models, we find that offspring of mothers with polycystic ovary syndrome have a higher risk of overall cardiovascular diseases and of its specific subtypes, independently of comorbidities related to polycystic ovary syndrome. Cousin analyzes suggest that familial confounding does not explain our results. If our findings are replicated by future studies, children of women with polycystic ovary syndrome may benefit from early cardiovascular prevention efforts.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-54795-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54795-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-54795-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().