MMP-2-triggered, mitochondria-targeted PROTAC-PDT therapy of breast cancer and brain metastases inhibition

Fan Tong, Yufan Wang, Yanyan Xu, Yang Zhou, Siqin He, Yufan Du, Wenqin Yang, Ting Lei, Yujun Song, Tao Gong and Huile Gao ()
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Fan Tong: Sichuan University
Yufan Wang: Sichuan University
Yanyan Xu: Sichuan University
Yang Zhou: Sichuan University
Siqin He: Sichuan University
Yufan Du: Sichuan University
Wenqin Yang: Sichuan University
Ting Lei: Sichuan University
Yujun Song: Sichuan University
Tao Gong: Sichuan University
Huile Gao: Sichuan University

Nature Communications, 2024, vol. 15, issue 1, 1-20

Abstract: Abstract Proteolytic targeting chimera (PROTAC) technology is a protein-blocking technique and induces antitumor effects, with potential advantages. However, its effect is limited by insufficient distribution and accumulation in tumors. Herein, a transformable nanomedicine (dBET6@CFMPD) with mitochondrial targeting capacity is designed and constructed to combine PROTAC with photodynamic therapy (PDT). In this work, we demonstrate that dBET6@CFMPD exhibits great biodistribution and retention, and can induce potent antitumor response to suppress primary and metastatic tumors, becoming a nanomedicine with potential in cancer combination therapy.

Date: 2024
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DOI: 10.1038/s41467-024-54854-2

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