Biodegradable Janus sonozyme with continuous reactive oxygen species regulation for treating infected critical-sized bone defects

Zixuan Ou, Junyu Wei, Jie Lei, Di Wu, Bide Tong, Huaizhen Liang, Dingchao Zhu, Hongchuan Wang, Xingyu Zhou, Hanpeng Xu, Zhi Du, Yifan Du, Lei Tan (), Cao Yang () and Xiaobo Feng ()
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Zixuan Ou: Huazhong University of Science and Technology
Junyu Wei: Huazhong University of Science and Technology
Jie Lei: Huazhong University of Science and Technology
Di Wu: Huazhong University of Science and Technology
Bide Tong: Huazhong University of Science and Technology
Huaizhen Liang: Huazhong University of Science and Technology
Dingchao Zhu: Huazhong University of Science and Technology
Hongchuan Wang: Huazhong University of Science and Technology
Xingyu Zhou: Huazhong University of Science and Technology
Hanpeng Xu: Huazhong University of Science and Technology
Zhi Du: Huazhong University of Science and Technology
Yifan Du: Huazhong University of Science and Technology
Lei Tan: Huazhong University of Science and Technology
Cao Yang: Huazhong University of Science and Technology
Xiaobo Feng: Huazhong University of Science and Technology

Nature Communications, 2024, vol. 15, issue 1, 1-23

Abstract: Abstract Critical-sized bone defects are usually accompanied by bacterial infection leading to inflammation and bone nonunion. However, existing biodegradable materials lack long-term therapeutical effect because of their gradual degradation. Here, a degradable material with continuous ROS modulation is proposed, defined as a sonozyme due to its functions as a sonosensitizer and a nanoenzyme. Before degradation, the sonozyme can exert an effective sonodynamic antimicrobial effect through the dual active sites of MnN4 and Cu2O8. Furthermore, it can promote anti-inflammation by superoxide dismutase- and catalase-like activities. Following degradation, quercetin-metal chelation exhibits a sustaining antioxidant effect through ligand-metal charge transfer, while the released ions and quercetin also have great self-antimicrobial, osteogenic, and angiogenic effects. A rat model of infected cranial defects demonstrates the sonozyme can rapidly eliminate bacteria and promote bone regeneration. This work presents a promising approach to engineer biodegradable materials with long-time effects for infectious bone defects.

Date: 2024
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DOI: 10.1038/s41467-024-54894-8

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